Table 1 Overview of phenotypic resistance of MDR strains to first-line and second-line antituberculosis drugs
From: On the onset and dispersal of a major MDR TB clone among HIV-negative patients, Tunisia
Resistance | Number of strains (%) | Gene | Mutations conferring drug resistance |
|---|---|---|---|
MDR | 64 (94,18) | ||
XDR | 4 (5,88) | ||
+ RIF | 68 (100) | rpoB | S531L, V615M |
+ EMB | 68 (100) | embB | M306I |
+ PZA | 43 (63.23) | pncA | A-11C Q10H C42A G10P L4W *Indel_Gene_Pos 341 CGT/C *Indel_Gene_Pos 297 G/GC *Indel_Gene_Pos 29 CTGCACGTCGACG/C *Indel_Gene_Pos 342 A/AC |
+ STM | 68 (100) | gidB | R47W |
+ INH | 68 (100) | katG | S315T |
+ ETO | 4 (5.88) | fabG1 | T-8C, C-15 T |
+ AMG | 4 (5.88) | rrs | A1401G |
+ FQ | 4 (5.88) | gyrB | D461H, G470C |
+ PAS | 0 | ||
+ CS | 0 |