Since Jan’10 different components of PCIP were progressively implemented (Hand hygiene program, Prevention of emergency and transmission of multidrug resistant microorganisms through isolation measures, environmental cleaning and antimicrobial stewardship, Care bundles for the prevention of device associated infections, and a Prevention program for surgical site infection). According to this strategy since Jul’10 an expanded surveillance system using National Healthcare Safety Network (NHSN) methodology was implemented. In order to evaluate the impact of PICP, the HAIs avoided were estimated by comparing infection rates, as events per 1000 patient-days, of two years (2011 vs 2012). All costs are expressed in US dollars. The local attributable cost of HAIs was estimated by adjusting the present value of previously reported data. The cost of PCIP was estimated from the incremental costs associated with human resources and the strategies implemented as part of the PCIP. Finally, the net savings was estimated as a difference between the incremental costs and direct costs avoided.