The study was performed as a double-blind, randomized, comparator-controlled, 3-arm, crossover study on 20 healthy volunteers with intact skin in a phase 1 study unit.
Test areas of 5 cm2 on the subjects‘ arms were treated with investigational and reference products using a polyurethane swab. Skin swabs were taken before and after treatment for quantitative microbial evaluation.
The main outcome measure was the log10 reduction factor (RF) of colony-forming units (cfu) on the skin after 30 minutes of treatment. Further endpoints were the RF after 5 and 10 minutes and the local tolerability.