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Nation-wide survey of screening practices to detect carriers of multi-drug resistant organisms upon admission to Swiss healthcare institutions
Antimicrobial Resistance & Infection Control volume 8, Article number: 37 (2019)
As emergence and spread of multi-drug resistant organisms (MDRO) requires a standardized preventive approach, we aimed to evaluate current MDRO admission screening practices in Swiss hospitals and to identify potential barriers impeding their implementation. In early 2018, all Swiss public and private healthcare institutions providing inpatient care were contacted with a 34-item questionnaire to investigate current MDRO admission screening policies. Among 139 respondents representing 180 institutions (response rate, 79%), 83% (149) of institutions implemented MDRO admission screening, while 28% of private and 9% of public institutions did not perform any screening. Targeted high-risk screening included carbapenemase producers, extended-spectrum beta-lactamase producers and methicillin-resistant Staphylococcus aureus at the institutional level for respectively 78% (115), 81% (118) and 98% (145) of screening institutions. Vancomycin-resistant enterococci (44% of institutions), multi-resistant Acinetobacter baumanii (41%) and Pseudomonas aeruginosa (37%) were systematically searched only by a minority of screening institutions. A large diversity of risk factors for targeted screening and some heterogeneity in body sites screened were also observed. Admission-screening practices were mostly impeded by a difficulty to identify high-risk patients (44%) and non-compliance of healthcare workers (35%). Heterogeneous practices and gaps in small and privately-owned institutions, as well as a mismatch between current epidemiologic MDRO trends and screening practices were noticed. These results highlight the need for uniform national MDRO screening standards.
Early detection of multi-drug resistant organisms (MDRO) carriage upon admission could allow timely implementation of infection control measures and the appropriate selection of empiric antimicrobial therapy . Few nationwide surveys investigated real-life MDRO screening practices upon admission [2,3,4,5]. In 2010, an unpublished survey conducted in Swiss intensive care units (ICUs) revealed heterogeneous MDRO screening practices. Endemicity among MDROs in Switzerland differs according to community or hospital settings. ESBL-producing Escherichia coli is considered as endemic in the general population, especially in the institutionalized elderly (extended-spectrum beta-lactamase (ESBL) E.coli prevalence of 22% among clinical isolates from nursing homes in 2017) , whereas acute care hospitals also consider methicillin-resistant Staphylococcus aureus (MRSA) - despite decreasing trends - (prevalence of 8% among clinical S. aureus isolates in 2014)  and ESBL-producing Klebsiella pneumoniae as endemic (7.7% of ESC-R invasive isolates in 2017) . The emergence and spread of MDRO requires a standardized preventive approach on a national scale. We therefore evaluated current MDRO admission screening practices in Swiss hospitals and identified potential barriers impeding their implementation.
From January to March 2018, a nation-wide 34-item questionnaire was sent to 228 Swiss public and private healthcare institutions providing inpatient acute care. Psychiatric institutions, nursing homes, palliative care and pain therapy centers were excluded. Three reminders as well as a phone call were addressed to each non-responding institution.
The survey was translated in the three official languages, pre-tested locally and shared through the online platform SurveyMonkey® (see French and German versions of the Online Survey, Additional files 1 and 2). We collected information about the characteristics of each hospital, in addition to current practices concerning universal and targeted MDRO screening for patients at-risk at admission, risk factors considered for targeted screening, body sites for sampling swabs and cultures, preemptive contact precautions for high-risk patients, the presence of local guidelines and problems faced to implement on-admission screening.
All analyses were institution-based (n = 180) and not respondent-based (n = 139), since some respondents were in charge of several institutions. Data were extracted from the online platform to an Excel® spread-sheet, checked for accuracy and exported for descriptive analysis using STATA 15.0® (StataCorp LLC, College Station, TX).
Overall, 139 respondents, mainly nurses (56%) and physicians (37%) replied for 180 institutions (response rate, 79%), with 57% from public institutions and 61% from small-size (< 200 beds), 21% medium-size, and 18% large-size institutions (> 500 beds). All non-responders were small-size institutions. The majority of hospitals (72%) was located in the Swiss-German part. Eighty-three percent of institutions (149) implemented some type of MDRO admission screening, while 28% of private and 9% of public institutions did not perform any screening. Universal MRSA screening of all admitted patients was not performed on an institutional level by any hospital, except for a few specific units in 6% of screening institutions. Targeted high-risk screening at the institutional level included carbapenemase-producing Enterobacteriaceae (CPE), ESBL-producing Enterobacteriaceae and MRSA, which were monitored by 78% (n = 115), 81% (n = 118) and 98% (n = 145) of hospitals, respectively (Table 1). Vancomycin-resistant enterococci (VRE) (44%), multi-resistant Acinetobacter baumanii (41%) and Pseudomonas aeruginosa (37%) were systematically searched only by a minority of institutions with on-admission screening programs, without differences between small and large institutions.
Frequently used risk factors to screen patients considered at high risk for MDRO carriage were “known carriers”, “hospitalization abroad” and a “direct transfer from abroad” (Table 2). Other risk factors are heterogeneously recognized among institutions. Of note, few hospitals (19%) systematically screen patients who have been transferred from other Swiss hospitals for VRE carriage, despite increasing VRE rates and ongoing outbreaks in Switzerland.
Heterogeneity subsists on the choice of body site sampling. Nares (99%), throat (81%) and inguinal sampling (91%) are leading body sites to screen for MRSA, whereas anal or rectal swabs are most frequently used for ESBL (89%), CPE (94%) or VRE (88%) screening. However, in some centers, inguinal screening was also performed for enteric bacteria. For MDR-A. baumanii and P. aeruginosa, a large variety of body sites were screened (anal, rectal, inguinal, throat or nasal swabs). For high-risk patients, only 23% (33/142) of hospitals routinely performed repeat swabs in case of one negative screening result. A total of 90% (86/96) of ICUs implemented pre-emptive contact precautions, including placement in a single room in 63% of ICUs.
Despite local recommendations for admission screening provided by 96% (137/142) of hospitals, these practices were mostly impeded by a difficulty to identify high-risk patients (44%) and non-compliance of healthcare workers (35%). Reimbursement issues were less commonly cited as an obstacle (15%).
This nation-wide survey to examine current practices of MDRO admission screening was answered by 180 institutions, representing an excellent response rate and the diversity of healthcare institutions in Switzerland, among public and private institutions of different sizes. This survey revealed good compliance with on-admission MDRO screening practices in larger acute-care hospitals, but also important gaps in small and private institutions.
This survey differs from previous national surveys evaluating MDRO screening practices at admission, mainly because of its higher response rate and the reporting of both risk factors and body sites sampled according to MDRO species [2,3,4,5]. Only one national survey performed in France in 2012 addressed public and private healthcare facilities. This survey observed that only 34% of 286 institutions reported management of patients at-risk at the time of admission .
A mismatch between the current epidemiologic situation and screening practices was noticed with a disproportionate focus on MRSA (in particular in patients transferred from the French and Italian speaking parts of Switzerland) and a lack of awareness of possible spread of A. baumanii, P. aeruginosa and VRE by unknown carriers, including patients transferred within Switzerland. Indeed, nosocomial MRSA incidence has been declining, whereas VRE rates are rapidly increasing [7, 9, 10]. In addition, severe nosocomial outbreaks of A. baumanii infections linked to imported cases have occurred in Switzerland in the past . Therefore, targeted high-risk screening should also include other MDROs beside MRSA.
A recent travel history to foreign countries without hospitalisation was rarely used as a risk factor to define high-risk patients eligible for screening at admission (23–29% of institutions according to the type of MDRO). This policy concerned in particular South-Asian countries with hyperendemic MDRO occurrence, such as India, Pakistan, Bangladesh, Nepal and Sri Lanka. A recent travel history to North America or U.S. citizenship were not considered as risk factors by any Swiss institution, despite increasing importation of community MRSA into Switzerland .
Heterogeneity was also observed among risk factors considered for targeted screening, probably due to a lack of national consensus on multiple criteria supporting surveillance programs. Adding to this complexity, actual controversies addressing admission screening policies support the requirement for updated and uniform standards: species to be screened, risk factors considered for targeted screening, number of screening swabs to be performed at admission, among others. Interestingly, cost considerations did not play an important role in implementing MDRO screening policies.
This survey has limitations. First, we were unable to perform external validation of the respondents’ answers. Second, this survey did cover neither screening practices beyond the admission procedure nor variability in MDRO control measures or laboratory detection methods. Third, the design of the study did not allow correlating MDRO screening practices to nosocomial MDRO transmission rates.
In summary, these results highlight the need for uniform national MDRO screening standards. It also demonstrates a lack of awareness about current MDRO trends, focusing on MRSA rather than VRE or gram-negative MDROs, and ongoing confusion about risk factors that might be addressed through uniform national standards. Harmonized, clear and accessible guidelines – which are already available in some countries – could support standardization of risk factors used for targeted admission screening and of sample sites for admission screening [13, 14].
Carbapenemase Producing Enterobacteriaceae
Intensive care unit
Multi-Drug Resistant Organism
Methicillin-Resistant Staphylococcus aureus
Lee AS, Cooper BS, Malhotra-Kumar S, et al. Comparison of strategies to reduce meticillin-resistant Staphylococcus aureus rates in surgical patients: a controlled multicentre intervention trial. BMJ Open. 2013. https://doi.org/10.1136/bmjopen-2013-003126.
Pan A, Bombana E, Tura G, et al. A survey of methicillin-resistant Staphylococcus aureus control strategies in Italy. Infection. 2013. https://doi.org/10.1007/s15010-013-0454-7.
Lepelletier D, Lucet JC, Astagneau P, et al. Control of emerging extensively drug-resistant organisms (eXDRO) in France: a survey among infection preventionists from 286 healthcare facilities. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol. 2015. https://doi.org/10.1007/s10096-015-2396-8.
Pogorzelska M, Stone PW, Larson EL. Wide variation in adoption of screening and infection control interventions for multidrug-resistant organisms: a national study. Am J Infect Control. 2012. https://doi.org/10.1016/j.ajic.2012.03.014.
Coppéré Z, Voiriot G, Blayau C, et al. Disparity of the “screen-and-isolate” policy for multidrug-resistant organisms: a national survey in French adult ICUs. Am J Infect Control. 2018. https://doi.org/10.1016/j.ajic.2018.05.025.
Kohler P, Fulchini R, Albrich WC, et al. Antibiotic resistance in Swiss nursing homes: analysis of National Surveillance Data over an 11-year period between 2007 and 2017. Antimicrob Resist Infect Control. 2018. https://doi.org/10.1186/s13756-018-0378-1.
Olearo F, Albrich WC, Vernaz N, et al. Swiss Centre for antibiotic resistance Anresis. Staphylococcus aureus and methicillin resistance in Switzerland: regional differences and trends from 2004 to 2014. Swiss Med Wkly. 2016. https://doi.org/10.4414/smw.2016.14339.
Federal Office of Public Health and Federal Food Safety and Veterinary Office. Swiss antibiotic resistance report 2018. Usage of antibiotics and occurrence of antibiotic resistance in Bacteria from humans and animals in Switzerland. 2018.
Moulin E, Deggim-Messmer V, Erard V, et al. Vancomycin-resistant enterocci (VRE) : a new reality in our hospitals. Rev Med Suisse. 2018.
Swiss Confederation. BAG - Informationsmagazin für medizinische Fachpersonen und Medienschaffende. Bulletin 18–2018. 2018.
Zanetti G, Blanc DS, Federli I, et al. Importation of Acinetobacter baumannii into a burn unit: a recurrent outbreak of infection associated with widespread environmental contamination. Infect Control Hosp Epidemiol. 2007. https://doi.org/10.1086/517956.
Von Dach E, Diene SM, Fankhauser C, et al. Comparative genomics of community-associated methicillin-resistant Staphylococcus aureus shows the emergence of clone ST8-USA300 in Geneva, Switzerland. J Infect Dis. 2016. https://doi.org/10.1093/infdis/jiv489.
Measures to Prevent and Control Transmission of Multidrug-Resistant Gram-Negative Bacilli in Acute Care Settings in Québec. INSPQ. https://www.inspq.qc.ca/en/publications/2131. Accessed 10 July 2018.
HCSP. Prévention de la transmission croisée des « Bactéries Hautement Résistantes aux antibiotiques émergentes » (BHRe). Paris: Haut Conseil de la Santé Publique; 2013. https://www.hcsp.fr/explore.cgi/avisrapportsdomaine?clefr=372. Accessed 10 July 2018
We would also like to thank Corinne Corradi, Isabelle Zenklusen, Laetitia Qalla-Widmer, Alexandra Peters and the infection control nurses at HUG for their precious help concerning the creation, translation and the distribution of this survey. We would like also to thank all participating institutions for their valuable collaboration.
This study was funded by the Swiss Federal Office of Public Health. The first author was partially supported by the Swiss National Science Foundation (grant agreement 407240_177454).
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This work (abstract P20) was presented in part at the Annual Meeting of the Swiss Society of Infectious Diseases, Interlaken, Switzerland; September 13, 2018.
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S.H. has participated in scientific advisory boards of DNA Electronics, Sandoz, GSK and Bayer; and has received financial support for research activities from the European Commission. The other authors declare no conflicts of interest.
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About this article
- Infection prevention and control
- Contact isolation
- Admission screening
- Multi-drug resistant
- Extended-spectrum beta-lactamase