Table 1 Demographic and clinical data of the study population (patients < 18 years)
Missing n (%) | All patients (n = 33) | VREfm-colonised patients (n = 26) | VREfm-colonised patients with suspected infection (n = 7) | p value* | |
|---|---|---|---|---|---|
Sex, n (%) | 0 (0.0) | ||||
Male | 20 (60.6) | 17 (65.4) | 3 (42.9) | 0.393 | |
Female | 13 (39.4) | 9 (34.6) | 4 (57.1) | ||
Age (in months) | 0 (0.0) | ||||
Median (range) | 6 (0–198) | 5.5 (0–198) | 13 (1–184) | 0.143 | |
Prematurity, n (%) | 4 (12.1) | ||||
Preterm born | 16 (48.5) | 14 (53.8) | 2 (28.6) | 0.632 | |
Mature born | 13 (39.4) | 10 (38.5) | 3 (42.9) | ||
Gestational age (in completed weeks of gestation) | 4 (12.1) | ||||
Median (range) | 34 (23–41) | 33.5 (23–41) | 34 (24–40) | 0.885 | |
Gestational weight (in grams) | 8 (24.2) | ||||
Median (range) | 2150 (465–4430) | 2150 (465–4430) | 1665 (730–2600) | 0.96 | |
Twin, n (%) | 0 (0.0) | ||||
Yes | 4 (12.1) | 4 (15.4) | 0 (0.0) | 0.555 | |
Invasive devices†, n (%) | 0 (0.0) | ||||
NG/NJ tube | 16 (48.5) | 13 (50.0) | 3 (42.9) | 1.000 | |
PEG/PEJ tube | 7 (21.2) | 6 (23.1) | 1 (14.3) | 1.000 | |
Peripheral venous catheter | 21 (63.6) | 15 (57.7) | 6 (85.7) | 0.223 | |
Central venous catheter | 17 (51.5) | 13 (50.0) | 4 (57.1) | 1.000 | |
Arterial line | 9 (27.3) | 6 (23.1) | 3 (42.9) | 0.358 | |
Port | 1 (3.0) | 1 (3.8) | 0 (0.0) | 1.000 | |
Hickman catheter | 5 (15.2) | 2 (7.7) | 3 (42.9) | 0.052 | |
Urinary catheter | 10 (30.3) | 6 (23.1) | 4 (57.1) | 0.161 | |
Ventricular drain | 3 (9.1) | 3 (11.5) | 0 (0.0) | 1.000 | |
Tracheostomy tube | 2 (6.1) | 2 (7.7) | 0 (0.0) | 1.000 | |
Chest drain | 2 (6.1) | 2 (7.7) | 0 (0.0) | 1.000 | |
Artificial stoma | 3 (9.1) | 0 (0.0) | 3 (42.9) | 0.006 | |
Surgical procedures†, n (%) | 0 (0.0) | 18 (54.5) | 11 (42.3) | 7 (100.0) | 0.009 |
Endoscopic procedure | 8 (24.2) | 7 (26.9) | 1 (14.3) | 0.652 | |
Cardiothoracic surgery | 4 (12.1) | 3 (11.5) | 1 (14.3) | 1.000 | |
Intrabdominal surgery | 5 (15.2) | 0 (0.0) | 5 (71.4) | < 0.0001 | |
Brain surgery | 2 (6.1) | 2 (7.7) | 0 (0.0) | 1.000 | |
Biopsy | 2 (6.1) | 1 (3.8) | 1 (14.3) | 0.385 | |
Bone marrow aspiration | 1 (3.0) | 0 (0.0) | 1 (14.3) | 0.212 | |
Tumour resection | 3 (9.1) | 0 (0.0) | 3 (42.9) | 0.006 | |
Other surgical procedures‡ | 2 (6.1) | 1 (3.8) | 1 (14.3) | 0.385 | |
Underlying diseases, n (%) | 0 (0.0) | ||||
Haemato-oncological diseases | 6 (18.2) | 2 (7.7) | 4 (57.1) | 0.011 | |
Cardiovascular diseases | 8 (24.2) | 6 (23.1) | 2 (28.6) | 1.000 | |
Diseases of the respiratory system | 13 (39.4) | 13 (50.0) | 0 (0.0) | 0.027 | |
Endocrine diseases | 3 (9.1) | 3 (11.5) | 0 (0.0) | 1.000 | |
Gastrointestinal diseases | 15 (45.5) | 11 (42.3) | 4 (57.1) | 0.674 | |
Genitourinary diseases | 3 (9.1) | 1 (3.8) | 2 (28.6) | 0.107 | |
Neurological diseases | 9 (27.3) | 8 (30.8) | 1 (14.3) | 0.642 | |
Malformation syndromes affecting multiple systems | 3 (9.1) | 2 (7.7) | 1 (14.3) | 0.524 | |
Chromosomal abnormalities | 3 (9.1) | 3 (11.5) | 0 (0.0) | 1.000 | |
Ventilation†, n (%) | 0 (0.0) | ||||
Invasive ventilation | 14 (42.4) | 10 (38.5) | 4 (57.1) | 0.422 | |
Non-invasive ventilation | 17 (51.5) | 13 (50.0) | 4 (57.1) | 1.000 | |
Chemotherapy⁓, n (%) | 0 (0.0) | ||||
Yes | 4 (12.1) | 1 (3.8) | 3 (42.9) | 0.023 | |
Reanimation⁓, n (%) | 0 (0.0) | ||||
Yes | 5 (15.2) | 3 (11.5) | 2 (28.6) | 0.282 | |
Overall hospitalisation before initial detection of VREfm° | 0 (0.0) | ||||
Length of stay (in days), median (range) | 38 (0–276) | 38 (0–276) | 28 (0–106) | 0.659 | |
Number of hospital admissions, median (range) | 1 (1–34) | 1 (1–34) | 1 (1–15) | 0.484 | |
Glycopeptide resistance genotype, n (%) | 0 (0.0) | ||||
vanA | 15 (45.5) | 14 (53.8) | 1 (14.3) | 0.095 | |
vanB | 18 (54.5) | 12 (46.2) | 6 (85.7) |