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Prevention of hospital-acquired pneumonia in non-ventilated adult patients: a narrative review



Pneumonia is one of the leading hospital-acquired infections worldwide and has an important impact. Although preventive measures for ventilator-associated pneumonia (VAP) are well known, less is known about appropriate measures for prevention of hospital-acquired pneumonia (HAP).


The purpose of this narrative review is to provide an overview of the current standards for preventing HAP in non-ventilated adult patients.


A search of the literature up to May 2015 was conducted using Medline for guidelines published by national professional societies or professional medical associations. In addition, a comprehensive search for the following preventive measures was performed: hand hygiene, oral care, bed position, mobilization, diagnosis and treatment of dysphagia, aspiration prevention, viral infections and stress bleeding prophylaxis.


Regarding international guidelines, several measures were recommended for VAP, whilst no specific recommendations for HAP prevention in non-ventilated patients are available. There is reasonable evidence available that oral care is associated with a reduction in HAP. Early mobilization interventions, swift diagnosis and treatment of dysphagia, and multimodal programmes for the prevention of nosocomial influenza cross-infection, have a positive impact on HAP reduction. The impact of bed position and stress bleeding prophylaxis remains uncertain. Systematic antibiotic prophylaxis for HAP prevention should be avoided.


Scant literature and little guidance is available for the prevention of HAP among non-ventilated adult patients. In addition, the criteria used for the diagnosis of HAP and the populations targeted in the studies selected are heterogeneous. Oral care was the most studied measure and was commonly associated with a decrease in HAP rate, although a broad range of interventions are proposed. No robust evidence is available for other measures. Further high-quality studies are required to evaluate the impact of specific measures on HAP prevention in non-ventilated adult patients.


During the first European point prevalence survey (PPS) of healthcare-associated infections (HAI) and antimicrobial use in acute care hospitals, the most frequently reported HAI types were respiratory tract infections (pneumonia 19.4% and lower respiratory tract 4.1%) [1]. In 2013, the second PPS of HAI and antimicrobial use in European long-term care facilities also reported that the most frequently types of HAI were respiratory tract infections [2]. In 2005, the classification of nosocomial pneumonia was defined by the American Thoracic Society and the Infectious Diseases Society of America (ATS/IDSA) and sub-classified “hospital-acquired pneumonia” (HAP), “ventilator-associated pneumonia” (VAP) and “healthcare-associated pneumonia” (HCAP) [3]. HAP is defined as a pneumonia occurring 48 h or more after hospital admission and VAP refers to pneumonia occurring more than 48–72 h after endotracheal intubation. HCAP refers to pneumonia developing outside the hospital, amongst patients in close contact with the healthcare system, which shares epidemiologic, bacteriologic and pathogenic features with HAP [3, 4]. The incidence of HAP ranges from 5 to more than 20 cases per 1000 hospital admissions [3, 5]. Outside the intensive care unit (ICU), highest rates are observed in the elderly, immunocompromised hosts, surgical patients and those receiving enteral feeding through a nasogastric tube [3]. Almost one-third of HAPs are ICU-acquired, with VAP accounting for 90% of those cases. Overall, VAP occurs in 9–40% of intubated patients, with decreasing incidence rates during the last decade [6, 7].

Risk factors identified for HAP are older age, male sex, structural lung disease and multiorgan system failure [3]. Gram negative bacteria are the most frequent etiologic agents of HAP, namely Pseudomonas aeruginosa, Klebsiella spp, Escherichia coli and Acinetobacter baumannii [3, 8]. Among Gram positive pathogens, methicillin-resistant Staphylococcus aureus (MRSA) is the most frequent pathogen, particularly in immunocompromised patients [3]. Compared with community-acquired pneumonia, HAP are more likely to be infections caused by multidrug-resistant (MDR) pathogens [9]. The frequency of MDR pathogens as the etiologic agents of HAP and VAP is increasing [10, 11]. Factors, including antibiotic use or hospitalization in the previous 3 months, immunosuppression and exposure to specific hospital units with high frequency of antibiotic resistance, influence the likelihood of MDR pathogens infection [12].

Patients developing HAP are more likely to die, require intensive care, mechanical ventilation, and to have longer hospital length of stay (LOS) than patients without HAP [13]. Aspiration is one of the pathologic mechanisms involved in HAP and is associated with supine position, dysphagia, altered mental status, esophageal motility disorders, vomiting, gastroesophageal reflux, tracheal intubation, enteral nutrition, nasogastric intubation, oropharyngeal and tracheobronchial colonization, tracheostomy and alcoholism [3, 8, 14, 15].

Although preventive measures for VAP are well known, less is known about appropriate measures for prevention of HAP [16]. Hence, preventive measures directed to individuals without mechanical ventilation are of great importance for patient safety, as well as mitigating the potential costs of HAP. In this narrative review, we provide an overview of the current standards and lack of evidence-based guidance concerning specific preventive measures against HAP in non-ventilated adult patients.

Literature search and selection strategy

A search for guidelines prior to May 2015 was performed using the electronic database Medline using the following terms: “pneumonia” AND (“nosocomial” OR “hospital-acquired”) AND “guidelines”. The results of this search were filtered to select for guidelines published by national professional societies or professional medical associations. An additional search was performed using Google Scholar and the Forum of European Respiratory Societies.

Medline was also used to search for articles published between January 2005 and May 2015 using the following terms: (“pneumonia” OR “respiratory tract infection” OR “respiratory infection”) AND (“nosocomial” OR “hospital-acquired” OR “healthcare associated” OR “healthcare-associated”) AND “prevention”. In addition, a review of each publications’ bibliography was performed to identify further pertinent articles.

For specific HAP prevention measures, a search using Medline for articles published prior to May 2015 was conducted using the following terms: (“pneumonia” OR “respiratory tract infection” OR “respiratory infection”) AND (“nosocomial” OR “hospital-acquired” OR “healthcare associated” OR “healthcare-associated”) AND:

  • (“hand hygiene” OR “hand washing”)

  • (“oral care” OR “oral hygiene” OR “oral decontamination” OR “oral health” OR “mouthwashes”)

  • (“bed position” OR “head position” OR “body position” OR “bed rest” OR “bed protocol”)

  • (“mobilization” OR “mobility” OR “motility” OR “physical activity” OR “physiotherapy”)

  • (“dysphagia” OR “swallowing” OR “swallowing disorder”)

  • (“aspiration” OR “aspirative”)

  • (“viral infection” OR “viral” OR “virus” OR “flu”)

  • (“stress bleeding prophylaxis” OR “gastric” OR “gastric protection” OR “acid-suppressive therapy” OR “acid-suppressive” OR “proton pump inhibitor” OR “omeprazol” OR “ranitidine”)

Articles published in English, French, Portuguese and Spanish were included in the review. Research was restricted to adult patients only. Studies performed on patients ventilated through a tracheal device (tracheal tube or tracheostomy) were excluded; studies performed on patients requiring non-invasive mechanical ventilation were included in the scope of the review. Studies which did not analyse the effect of any prevention measure were also excluded. Focus was placed on identifying the most relevant publications, namely meta-analyses, systematic reviews and studies containing results from randomized control trials (RCT) except for mobilization where all relevant studies were included. Some infection control bundle studies were also included when relevant.

Professional societies’ guidelines and recommendations

There are several recommendations for pneumonia prevention issued by international guideline committees and professional societies. Although recommendations differ, all of the guidelines available focus on VAP prevention and not specifically on prevention of pneumonia outside the ICU (Table 1). General agreement was found for the following VAP preventive measures: hand hygiene, microbiologic monitoring, bed elevation, oral care with antiseptic, use of orogastric tubes, avoidance of endotracheal intubation and promotion of non-invasive ventilation [3, 8, 1728]. Physiotherapy or mobilization as a preventive measure for VAP has not been equally addressed by the different societies. Among VAP prevention recommendations, some measures could theoretically also target HAP prevention, such as hand hygiene, oral care with antiseptic, aspiration prevention, bed elevation and early mobilization.

Table 1 Guidelines and recommendations for the management of hospital-acquired pneumonia, ventilator-associated pneumonia and healthcare-associated pneumonia

Measures for HAP prevention

The heterogeneity of the interventions investigated (hand hygiene, oral care, prevention of aspiration and dysphagia, bed position, mobilization, prevention of viral infections, antibioprophylaxis and stress-bleeding prophylaxis) did not permit a meta-analysis.

Hand hygiene

Hand hygiene is an effective measure to prevent HAI [2932]. Nevertheless, no clinical trial has demonstrated its efficacy for decreasing specifically pneumonia outside the ICU. Pittet et al. [29] showed that access to bedside antiseptic handrubs contributed to an increase in hand hygiene compliance leading to an overall significant reduction in nosocomial infection prevalence (from 16.9 to 9.9%). Hence, the implementation of programmes to enhance hand hygiene adherence by health care workers (HCWs) and use of alcohol-based disinfectants could potentially contribute to HAP reduction, but further studies are needed to demonstrate its preventive effectiveness, independent of other measures.

Oral care

Aspiration of oropharyngeal secretions is an important pathogenic event preceding HAP. Silent aspiration into the intrathoracic airway occurs in normal subjects and is more pronounced in elderly and neurologically impaired patients [15, 33]. The impact of oral care in reducing respiratory tract infections, HAP and mortality has been documented in several clinical trials and has been subject to systematic reviews and meta-analysis [3437]. Three systematic reviews and one meta-analysis addressing the preventive effect of oral hygiene in pneumonia among individuals staying at health-care facilities were selected (Table 2).

Table 2 Systematic reviews about the association between oral care and reduction in pneumonia or respiratory tract infection

Azarpazhooh et al. [37] conducted a systematic review to examine the evidence for a possible etiological association between oral health and pneumonia. The review found that presence of cariogenic and periodontal pathogens in saliva and dental plaque, dental decay and poor oral hygiene were potential risk factors for HAP. Ten studies analysing the impact of oral care interventions in the incidence or progression of pneumonia were analysed; three of them were not randomized. The interventions included in the studies were: professional dental care, mouthrinse with 0.12% chlorhexidine (CHX), application of 0.2% CHX gel, 1% povidone-iodine (PVI) scrubbing of pharynx, topical application of a non-absorbable antibiotic solution and topical antimicrobial prophylaxis. Studies were performed in ICUs (n = 6), nursing homes (n = 3) and in a general hospital (n = 1). Except for 1 study, all studies showed that interventions reduced the incidence of pneumonia and/or the length of mechanical ventilation. Overall, this review found a relative risk reduction in pneumonia incidence between 34 and 83% following oral decontamination techniques.

Sjorgen et al. [36] conducted a systematic review focusing on the preventive attributes of oral hygiene (0.12% CHX oral rinse, tooth-brushing, 1% PVI scrubbing of pharynx or professional mechanical oral health care weekly) on pneumonia and respiratory tract infection among hospitalized elderly people and elderly nursing home residents. It included five RCTs and 10 non-randomized intervention studies, all suggesting an association between poor oral hygiene and pneumonia in dependent elderly people. Data from the included RCTs were not considered for meta-analysis because of the heterogeneity in primary endpoints, methodological quality and study design. The analysis revealed an absolute risk reduction between 6.6 and 11.7% for pneumonia, respiratory tract infection and death from pneumonia.

A meta-analysis investigating the effect of oral care on pneumonia among non-ventilated patients was conducted by Kaneoka et al. and included five RCTs, two of which assessed the use of CHX in hospitalized patients and the remaining three the impact of mechanical oral cleaning among nursing home residents [34]. A significant risk reduction for pneumonia (relative risk (RR) 0.61, 95% CI 0.40–0.91) as well as a risk reduction for fatal pneumonia (RR 0.41, 95% CI 0.23–0.71) were observed. However, these results should be interpreted with caution. The majority of the RCTs were at high risk of selection bias in that they did not include participants with risk factors for pneumonia, such as patients with nasogastric tubes or severe dementia. Furthermore, a precise and reproducible definition of pneumonia was not provided in two RCTs.

El-Rabbany et al. [35] updated the Azarpazhoo et al. systematic review in 2015, including the only RCTs which evaluated the impact of different health care strategies on incidence of HAP and VAP. Twenty-eight RCTs were selected for analysis and addressed the following interventions: 1) professional dental care, 2) sodium bicarbonate mouthrinse, 3) toothbrushing, 4) 0.12 and 0.2% CHX, 5) topical application of a non-absorbable antibiotic solution and 6) PVI swab. Although all included trials had a randomized controlled design, the risk-of-bias evaluation revealed that the majority of the included studies presented with a moderate to high risk of bias [38]. Overall, the use of oropharyngeal decontamination using various antimicrobial interventions was suggested to be associated with a reduction in both VAP and HAP. Twelve of the 17 studies reviewing the efficacy of CHX failed to demonstrate a significant effect. The effectiveness of other measures such as tooth brushing or iodine swab remained uncertain.

Prevention of aspiration and dysphagia

Dysphagia is the most important risk factor for aspiration pneumonia, especially in elderly and acute stroke patients. It is estimated that 43–54% of stroke patients with dysphagia aspirate and 37% of the later will develop pneumonia [39].

A systematic review published in 2001 including 1808 studies analysed dysphagia programmes and prevention of pneumonia among post-stroke patients, mainly focusing on the methodology used for the diagnosis of dysphagia [39]. The diagnostic methods analysed were: 1) patients’reports of swallowing difficulty, 2) bedside program evaluation, 3) videofluoroscopic study of swallowing and 4) fiberoptic endoscopic examination of swallowing. Although no RCTs were found in the search, the implementation of a systematic programme for diagnosis and treatment of dysphagia in acute stroke patients seemed to substantially reduce pneumonia rates compared with historical controls in 4 different case series. The small size of available studies did not allow determination of the relative efficacy of different diagnostic methods.

Foley et al. conducted in 2008 a systematic review including 15 RCTs that analysed the treatment of dysphagia in post-stroke patients in respect of death, return to functional swallowing and pneumonia [40]. The treatments analysed in the review were: 1) texture-modified diets, 2) swallowing therapy programmes, 3) non-oral feeding, 4) use of medications (nifedipine) and 5) physical stimulation (aromatherapy, cold stimulus of the faucial pillars). According to the authors, the methodological quality of the trials was only fair. Due to the small number of trials found in the search as well as the heterogeneity of treatments and outcomes evaluated, limited evidence was found to support a specific treatment for dysphagia. Nevertheless, the analysis performed suggested that nasogastric tubes do not appear to increase the risk of death when compared with percutaneous endoscopic gastrostomy feeding tubes. Furthermore, general swallowing programs were associated with a pneumonia risk reduction in acute stroke patients.

Bed position

The positioning of mechanically ventilated patients in a semi-recumbent position for preventing pneumonia has been advocated for more than a decade [3, 8, 1728]. However, the possible impact of semi-recumbent position in HAP prevention among non-ventilated patients has not been extensively studied.

In 1992, a RCT including 45 dependent patients admitted to a Japanese geriatric hospital analysed the impact of bed elevation for at least two hours after each meal and daily cleaning of the oropharynx (gargling for a few minutes with PVI) compared to standard care in the prevention of respiratory tract infections [41]. Febrile days were significantly decreased (up to 4 days) in the intervention group compared to the control group. However, which measure (oral hygiene or bed elevation) contributed more to the reduction in febrile days could not be assessed in this study.

Loan et al. conducted a RCT including 229 adults and children with tetanus admitted to a Vietnamese hospital [42]. The intervention group was assigned to a semi-recumbent position of 30°. The study included ventilated and non-ventilated patients as well as tracheostomized subjects. Development of pneumonia and mortality did not differ between the intervention (semi-recumbent position) and control group (supine position). In fact, an increase in the overall complication rate (65.0% versus 50.9%, p = 0.03) and a need for tracheostomy (58.9% versus 45.5%, p = 0.04) were observed in the intervention group. Thus, clinicians should be aware of the risk that non-ventilated patients may often change their positioning and may even increase the likelihood of microaspirations and further complications.


Development of HAP is associated with a reduction in respiratory secretions’ clearance, which in turn is related to physical inactivity. Some recommendations for VAP prevention include physiotherapy and early mobility programmes [3], but sparse data is available for HAP prevention.

Cuesy et al. conducted a RCT evaluating the preventive effect of a “turn-mob” program for HAP [43]. The study included 223 non-ventilated patients with acute ischemic stroke. The intervention group (n = 111) was submitted to the “turn-mob” program, the later consisting of modifying the patient from supine to right and left lateral recumbent position every two hours and passive mobilization of the limbs every 6 h. The intervention was carried out by previously trained relatives of the patient. The control group (n = 112) was submitted to change of position by the nursing staff 3 times per day. Performing passive mobilization and postural changes was associated with a 61% relative decrease in the incidence of HAP (intervention group- 12.6% versus control group- 26.8%; RR 0.39, 95% CI 0.19–0.79). Of note, the high HAP incidence (19.7%) observed in this study is twice the rate usually reported for acute stroke patients [44]. Furthermore, the turn-mob program was performed every two hours; thus, wide implementation of this strategy, carried out by patient family members or by HCWs, seems to be too cumbersome and time-consuming to be applied broadly.

A prospective cluster study including 1179 subjects from elderly and respiratory care compared the effect of an early mobility bundle programme in one hospital to usual care in a second one [45]. The primary outcome was incidence of HAP. The intervention consisted of enhancing measures and equipment (availability of walking aids, of mobility charts, education…) in order to maximize patients’mobility. After adjustement on admission condition, age and patient comorbidity, the intervention remained associated with lower incidence of HAP with a hazard ratio of 0.39 (95% CI 0.22–0.68). But these results should be interpreted with caution: patients were not randomized and there were some significant differences between the groups in terms of demographics and comorbidities; falls were significantly higher in the intervention group in comparison with the control group (29.2% versus 18.4%). Randomized studies are warranted to prove clinical effectiveness and lack of adverse events of this kind of intervention for elderly patients.

Other preventive interventions

Besides the above mentioned interventions, other preventive measures have been considered for the prevention of HAP.

Viral infections- among patients with HAP, approximately 20% are due to viral pathogens and are associated with increased morbidity and mortality [46, 47]. Respiratory viral infections, especially influenza and respiratory syncytial virus, affect mainly immunocompromised patients and nosocomial transmission is common [48]. Multimodal interventions including 1) contact and droplet precautions, 2) cohort nursing, 3) influenza vaccination of HCW and high risk populations, 4) chemoprophylaxis to residents in long term care facilities during an influenza outbreak and 5) generalized use of masks irrespective of vaccination status have shown to be effective in prevention of nosocomial spread of influenza and other respiratory viruses [46, 4850].

Antibioprophylaxis- acute stroke patients are especially vulnerable to infections due to diverse factors: swallowing disturbances, altered mental status, use of invasive procedures (urinary catheterisation; mechanical ventilation) and immunodepression [51]. Considering the higher risk of infection among these patients, a possible benefit by preemptive antibiotic therapy has been considered. A Cochrane systematic review found six RCTs including 506 acute ischemic or haemorrhagic stroke patients. Of these, five were included in a meta-analysis and identified a significant reduction in the general infection rate from 36 to 22% with antibiotic prophylaxis [51]. A recent multicentre RCT included 2538 patients with acute stroke to investigate the effect of intravenous ceftriaxone (2 g daily for 4 days) in the functional outcome at 3 months (modified Rankin Scale), infection rates, death, antimicrobial use and LOS [52]. Although the intervention group had a significant reduction in the rates of overall infection (odds ratio (OR) 0.44, 95% CI 0.30–0.65), the same effect was not observed for pneumonia (OR 0.67, 95% CI 0.39–1.15). Neither functional outcome, nor mortality or LOS was reduced with the intervention, and therefore, there is currently not enough evidence of benefit from the use of prophylactic antibiotics in acute stroke patients.

Stress-bleeding prophylaxis- increase in gastric pH can lead to an increase in bacterial colonization. Sultan et al. [53] have performed a meta-analysis to examine the association between proton pump inhibitors (PPIs) treatment and respiratory infections. They included 7 RCTs and showed a trend towards an association between PPIs and respiratory infections, although it failed to reach statistical significance (OR 1.42, 95% CI 0.86–2.35; P = 0.17). Eom et al. [54] have studied the association between the use of acid-suppressive drugs and the risk of pneumonia. Meta-analysis of 23 RCTs examining risk of HAP in association with use of histamine-2 receptor antagonists showed a higher risk of HAP among subjects receiving those drugs (RR 1.22, 95% CI 1.01–1.48). Of note, few RCTs have been performed outside the ICU setting.

Multimodal strategies- Juthani-Metha et al. conducted a cluster RCT evaluating the impact of a multimodal intervention protocol for pneumonia prevention among 834 elderly people residing in 36 nursing homes [55]. The study was limited to patients at high risk for pneumonia (residing at a nursing home for at least 1 month, and who had at least one of two risk factors for pneumonia: impaired oral hygiene; swallowing difficulty) which does not represent the entire elderly population residing in nursing homes [56]. The intervention consisted of manual tooth/gum brushing and 0.12% CHX oral rinse twice daily, plus maintaining an upright position during feeding. The intervention did not reduce the incidence of pneumonia nor respiratory tract infections compared to usual care. Of note, the trial was terminated early for futility.


Data concerning prevention of HAP in non-ventilated adult patients, breathing without assistance through a tracheal tube is scarce and of a poor quality. Therefore formal recommendations and evidence-based guidelines are not available. This is in contrast to VAP prevention that encompasses a large body of evidence and important research efforts, leading to strong guidelines and recommendations from professional societies.

Regarding oral care, the majority of studies included in reviews and meta-analyses had a high risk of bias and there was heterogeneity concerning the type of interventions studied. Nevertheless, chemical oral care is associated with a reduction in HAP and mortality [3537]. Further studies are needed to clarify the impact of specific measures (CHX, toothbrush, PVI and professional oral care), their optimal frequency, and whether there is an existence of a synergistic combination of different oral care interventions on HAP prevention.

Implementation of systematic programs for the diagnosis and early treatment of dysphagia may lead to dramatic reductions in HAP rates among neurologically impaired patients [39, 40]. Further studies are needed to define the best diagnostic approach as well as the best treatment modality for dysphagia.

Implementation of multimodal programs for the prevention of nosocomial transmission of viral infections, especially seasonal and pandemic influenza is a cornerstone of HAP prevention during winter season [49]. Universal use of mask irrespective of vaccination status is effective in reducing nosocomial transmission of influenza, but may be difficult to implement [57, 58]. HCW vaccination, cohort nursing and antiviral prophylaxis for high risk patients during an outbreak reduce transmission and the deleterious consequences of influenza infection, including lower respiratory tract infections [46, 48].

Although only two studies were found, early mobilization interventions appear to reduce HAP incidence [45]. Post-stroke patients in particular could benefit from early mobilization, especially in the 48 h after the ischemic event [43]. But the benefit/risk balance of intensive programs needs to be further evaluated, monitoring also the risk of falls.

We were unable to make definite conclusions regarding the impact of bed position or stress bleeding prophylaxis on HAP due to the small number of studies performed as well conflicting results between them. Systematic antibioprophylaxis for HAP prevention should be avoided.

Although no clinical trial has demonstrated efficacy of hand hygiene for decreasing specifically HAP, standard precautions and cleaning practices are the cornerstone to reduce cross-infection. Focusing prevention on reservoirs, with good respect of hand hygiene, and the portal of entry, by improving basic oral care, may be the most realistic approaches for preventing HAP in non-ventilated patients.

A number of limitations should be kept in mind regarding the available evidence. Firstly, the criteria used for HAP diagnosis were heterogeneous across the literature. Second, few RCTs were found concerning most preventive measures, and some studies had small sample sizes. Third, the populations targeted in the studies, the interventions and the outcomes analysed were very heterogeneous.

In conclusion, for clinical practice, the following measures may be recommended for non-intubated adult patients despite the above-cited methodological limitations: 1) to respect the five moments for hand hygiene [59], 2) to perform daily oral care with antiseptics, 3) to implement a systematic programme for diagnosis and treatment of dysphagia among post-stroke patients, 4) to implement interventions for preventing the nosocomial spread of viral infections during winter season, 5) to support early mobilization of patients by taking into account the risk of falls, 6) to avoid systematic antibiotic prophylaxis for HAP prevention. The effect of bed position, acid-suppressive drugs as well as the synergistic effect of more than one preventive measure on HAP incidence needs to be evaluated in further controlled trials.



American Thoracic Society / Infectious Diseases Society of America




Healthcare-associated infections


Hospital-acquired pneumonia


Healthcare-associated pneumonia


Health care workers


Intensive care unit


Length of stay




Methicillin-resistant Staphylococcus aureus


Odds ratio


Proton pump inhibitors


Point prevalence survey




Randomized control trials


Relative risk


Ventilator-associated pneumonia


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We thank Ross Leach for language assistance.


This review was partially supported by the Combacte Consortium, which is supported by the IMI Joint Undertaking under the Combacte grant agreement number 115523, the resources of which are composed of financial contribution from the European Union’s 7th Framework Programme and the European Federation of Pharmaceutical Industries and Associations companies’ in-kind contribution.

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Authors’ contributions

L.P. and C.L. analyzed and interpreted the litterature regarding the current standards for preventing HAP in non-ventilated patients. S.H. was a major contributor in writing the manuscript. All authors read and approved the final manuscript.

Competing interests

S.H. reports having received a peer-reviewed research grant funded by Pfizer; he is also a member of the advisory boards of Destiny Pharma, bioMerieux, Novartis, and DaVolterra. All other authors: none to declare.

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Correspondence to Caroline Landelle.

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Pássaro, L., Harbarth, S. & Landelle, C. Prevention of hospital-acquired pneumonia in non-ventilated adult patients: a narrative review. Antimicrob Resist Infect Control 5, 43 (2016).

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