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Antimicrobial dispensing process in community pharmacies: a scoping review

Antimicrobial Resistance & Infection Control volume 11, Article number: 116 (2022) Cite this article

Abstract

Background

Antimicrobial resistance remains a major global public health concern, and antimicrobial dispensing in community pharmacies is an important factor in preventing this damage. However, the current literature focuses on the technical and attitudinal aspects related to antimicrobial dispensing, with little emphasis on the interventions provided in this service. Thus, this study aimed to determine the antimicrobial dispensing process in community pharmacies.

Methods

A scoping review was performed in September 2020 using the PubMed, EMBASE, LILACS, Web of Science, and Cochrane databases. The search terms included words related to dispensing, antibacterial agents, and pharmacies in various combinations. Two reviewers screened the titles, abstracts, and full-text articles according to the eligibility criteria, and extracted the data. The findings were presented in a descriptive form.

Results

Of the 7713 studies screened, 35 were included, of which 22 (63%) were published in Asia. Most studies followed a cross-sectional design (n = 27), and the simulated patient was the most often used method to assess the antimicrobial dispensing process (n = 22). Moreover, 31 (89%) studies investigated antimicrobial dispensing without prescription, and only four (11%) studies evaluated antimicrobial dispensing with prescription. In the 35 studies, the most frequently asked questions were about drug allergies (n = 19) and patient symptoms (n = 18), and counseling mainly focused on the side effects (n = 14), precautions (n = 14), how to take the medication (n = 12), and duration of medication use (n = 11). Another common intervention was referral (n = 15). Among clinical cases, counseling on medication use occurred often in cases of urinary tract infection (51%) and otitis media (50%).

Conclusions

Antimicrobial dispensing processes have been primarily investigated in low- and middle-income countries, with a focus on dispensing antimicrobials without prescriptions. During the dispensing process, pharmacists mostly posed minimal questions and counseling, highlighting the deficiencies that persist in this practice. Our results indicate the need for multifaceted strategies, such as implementing educational, regulatory or administrative strategies and changes in cultural background, especially in low- and middle-income countries, that aim to reduce indiscriminate use of antimicrobials. Therefore, qualifying the antimicrobial dispensing process is a fundamental factor for improving the rational use of antimicrobials and reducing microbial resistance.

Background

The development of antimicrobials has been one of the most significant events in modern medicine over the past century [1]. However, their indiscriminate use has become a growing public health concern as antimicrobials have been strongly implicated in the development of microbial resistance [2, 3]. Globally, microbial resistance is responsible for an estimated 700,000 deaths per year, which could increase to as much as 10 million by 2050 if this problem is not addressed [4, 5]. In the United States, microbial resistance has caused an estimated two million infections and 23,000 deaths, with an annual economic impact of US$ 55–70 billion [6].

In this context, health systems worldwide face the challenge of addressing microbial resistance. According to the World Health Organization, approximately 93% of access to antimicrobials comes from community pharmacies [7]. From this perspective, pharmacists can be considered the last barrier during the dispensing process, capable of preventing inappropriate use of antimicrobials and the possible health problems that could result from such use [8]. The dispensing has wide visibility in community pharmacies, is highly accessible, and serves many patients seeking treatment-related counseling and medicine [9].

Drug dispensing is a service that ensures the provision of medicines and other health products through analysis of the technical and legal aspects of a prescription, assessment of individual health needs, and medical intervention through pharmaceutical counseling and documentation [10, 11]. A well-structured dispensing process can become a valuable service because it can limit indiscriminate antimicrobial use, and therefore, microbial resistance [12].

Studies have indicated that interaction between pharmacists and patients enables interventions that optimize the use of antimicrobials in community pharmacies [13]. Despite this, there is little scientific evidence on the panorama of antimicrobial dispensing practices and interventions provided by pharmacists. Previous studies have focused on the frequency and proportion of the sale of antimicrobials without prescriptions in community pharmacies, and the main diseases, and antimicrobials involved in these practices [13,14,15], as well as pharmacists’ perceptions of antimicrobial sales without prescription [8, 16].

Thus, there remains a gap in the way this service is provided to patients, with little emphasis placed on the dispensing process; in other words, how the dispensing service has been provided to patients and what pharmacist interventions have been carried out during this service. Therefore, exploring pharmacist interventions will optimization of the antimicrobial dispensing service, and development of strategies that mitigate the burden of microbial resistance and its impacts on society.

Hence, studying antimicrobial dispensing processes in community pharmacies worldwide is important. An understanding of the behaviors, counseling, and interventions provided by pharmacists during antimicrobial dispensing, will help to develop strategies that address the gaps in this service and improve the dispensing process in community pharmacies. Therefore, this study aimed to determine the antimicrobial dispensing process in community pharmacies.

Methods

Study design

This scoping review adopted the methodology described in the Joanna Briggs Institute Reviewer’s Manual [17] and was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR) criteria [18]. Scoping Review was performed as the objective of the present study was to map, or identify, the available literature related to the process of dispensing antimicrobials [19].

Identification and development of research questions

As this review mainly focused on the antimicrobial dispensing process, the research question was “what are the antimicrobial dispensing processes in community pharmacies?” Based on this research question, five areas of interest were identified.

  • RQ1: What are the most frequently dispensed classes of antimicrobials?

  • RQ2: What are the methods used to evaluate antimicrobial dispensing?

  • RQ3: What is the main counseling provided to patients by pharmacists and the pharmacy team during antimicrobial dispensing?

  • RQ4: What are the others interventions performed by pharmacists and the pharmacy team for patients during antimicrobial dispensing?

  • RQ5: How do studies assess the quality of antimicrobial dispensing?

Search strategy

A literature search was performed in September 2020 using the following databases: PubMed/MEDLINE, LILACS, Cochrane, Web of Science, and Embase. The search strategies were drafted according to a database protocol using search terms related to dispensing, anti-bacterial agents, and pharmacies and their combinations. The search strategy employed both standardized terms from the controlled vocabulary of the “National Library of Medicines” through the “Medical Subject Headings (MESH)” and non-standard terms to extend the search. The “All fields” search option was used. No date limit was used in the database search and relevant studies published up to September 2020 were identified. The full search is available in the Additional file 1.

Study selection

Two reviewers (E.V.S. and L.J.S.C.V.) independently screened the search results using the Rayyan tool (http://rayyan.qcri.org) [20], and identified potentially relevant studies based on their titles and abstracts. Relevant studies were read in full and selected according to the eligibility criteria. Disagreements between the two reviewers were resolved by a third reviewer (S.C.S.).

Eligibility criteria

The study selection criteria were established according to the population-concept-context framework, as recommended by the Joanna Briggs Institute for scoping reviews [17]:

  • Population: community pharmacists and pharmacy team

  • Concept: antimicrobial dispensing process

  • Context: community pharmacy

Inclusion criteria

Studies that met the following criteria were included: (i) original articles; (ii) studies published in English, Portuguese, and Spanish; (iii) studies exploring antimicrobial dispensing processes; (iv) studies performed in community pharmacies; (v) studies that evaluated interventions during dispensing; and (vi) studies with pharmacists and pharmacy team as participants. No limitations were applied in terms of the publication year or study design.

Exclusion criteria

The following studies were excluded: (i) academic documents such as theses and dissertations; (ii) studies without full text available; (iii) meta-analyses, systematic reviews, narrative reviews, letters, editorials, commentaries, posters, and conference proceedings; and (iv) studies in which separating antimicrobial dispensing data from those of other drug classes was not possible.

Data extraction

A standardized data graph form was created, and data extraction was performed in duplicate. The initial categories included general study characteristics such as authors, year of publication, country, study objective, study design, and sample. Information was collected on antimicrobial dispensing practices, including antimicrobial dispensing with and without prescription, methods for evaluating the dispensing of antimicrobials and assessing the quality of dispensing, classes of antimicrobials dispensed/studied, and limitations. In the present study, evaluation of dispensing quality focused on the instruments or quality indicators used by the studies that reported minimal counseling or other interventions provided by pharmacists for the rational use of medicines.

Analysis and presentation of the results

The findings were presented in a descriptive form. Figures and tables were used as appropriate to illustrate or summarize the key findings.

Results

Search results

A total of 4887 articles were identified during the initial search. After excluding duplicates (n = 2826) and irrelevant articles based on the titles and abstracts (n = 4760), 127 potentially relevant articles were retrieved for full-text evaluation. Of these, 35 met the inclusion criteria and were included in the scoping review [21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55] (Fig. 1).

Fig. 1
figure 1

Flow diagram of literature search and screening process

Full size image

Characteristics of the selected studies

A description of the general characteristics of the 35 included studies is provided in Table 1. These studies were published between 2006 and 2020, and 22 (63%) were conducted in Asia, 7 (20%) in Africa, 4 (11%) in Europe, 1 (3%) in North America, and 1 (3%) in South America. Regarding study design, 31 studies were cross-sectional, 3 were qualitative, and 1 used more than one study design (mixed methods). Moreover, 31 (89%) studies investigated the practice of antimicrobial dispensing/sales without prescription, and only four (11%) studies evaluated the same with prescriptions. We did not observe any difference in the antimicrobial dispensing process with or without prescriptions.

Table 1 Characteristics of the selected studies
Full size table

Classes of antimicrobials most often dispensed/studied

Among the classes of antimicrobials most addressed by the studies, were penicillins (n = 54; 33.1%), with amoxicillin and amoxicillin + clavulanate being the most recurring regimens, followed by macrolides (n = 26; 15.9%), cephalosporins (n = 25; 15.3%), quinolones (n = 25; 15.3%), lincosamides (n = 9; 5.5%), aminoglycosides (n = 6; 3.7%), tetracyclines (n = 6; 3.7%), sulfonamides (n = 6; 3.7%), and others (n = 6; 3.7%) (Table 2).

Table 2 Antimicrobials dispensing practices of studies
Full size table

Methods used to evaluate antimicrobial dispensing process

Of the 35 studies included in this review, 22 (63%) used the simulated patient method to evaluate antimicrobial dispensing and 13 (37%) used face-to-face interviews, questionnaires, and pharmacist documentation methods (Table 2). In studies that used the simulated patient method, the main scenarios were related to the following health conditions: sore throat, diarrhea, respiratory tract infection, urinary tract infection, and otitis media. The study samples were heterogeneous and varied from 6 to 2,411 community pharmacies and 98 to 202 pharmacists.

Antimicrobial dispensing process

Regarding dispensing antimicrobials, community pharmacists and pharmacy team asked questions more frequently than provide counseling or other interventions. Of the 35 studies, the most frequently asked questions were about drug allergies (n = 19, 54.3%), patient symptoms (n = 18, 51.4%), and the use of other medicines (n = 13, 37.1%). The main counseling provided by community pharmacists was about the side effects (n = 14, 40%), and precautions (n = 14, 40%), how to take the medicine (n = 12, 34.3%), and duration of medication (n = 11, 31.4%). In addition, seven other interventions were performed, of which referral was the most common (n = 15, 42.8%), followed by refusal to dispense antimicrobials without prescription (n = 12, 34.3%) (Table 2).

The process of dispensing antimicrobials in clinical cases is presented in Table 3. It was observed that for most cases, the pharmacists asked about patient symptoms, of which cough (78%) and common cold (51%) were the most common. Among clinical cases, counseling on how to take the medicine was most frequent in cases of urinary tract infection (51%) and otitis media (50%), followed by how long the medication should be taken in cases of urinary tract infection (42%) and otitis media (40%). Regarding other interventions, the most frequent was referrals, with the highest frequencies for acute sinusitis (26%) and otitis media (23%). Of note, no study reported the evaluation of antimicrobial dispensing quality.

Table 3 Practices of antimicrobials dispensing for clinical cases
Full size table

Discussion

Despite extensive literature on antimicrobial dispensing, most studies have focused on dispensing antimicrobials without prescriptions. This is especially true in the low- and middle-income countries in Asia and Africa. Corroborating these data, a systematic review by Batista et al. [16] identified that the highest percentage of dispensing antimicrobials without prescription occurred in Asia. Among the main factors that contribute to this practice are the unavailability and inaccessibility of health facilities, economic benefits to the pharmacy team, limited knowledge of antimicrobials among the population and pharmacy team, lack of information about the negative impact of this practice, and ineffectively imposed regulations [16, 56,57,58]. Therefore, multifaceted strategies should be developed to address these problems, including population awareness and professional qualifications, to reduce inappropriate antimicrobial use.

Most of the studies included in this review used the simulated patient method to assess the antimicrobial dispensing process. The simulated patient method consists of the visit of a trained individual to the pharmacy, indistinguishable from a genuine patient, who enacts predetermined scenarios, to assess information gathering and counseling provided by pharmacists in the supply of medicines. Simulated patient methods provide an unobtrusive means of observing actual practice behavior and are considered the ‘gold standard’ for the measurement of the quality of behavior [59,60,61]. Furthermore, this method has considerable advantages over other methods for assessing service quality as it minimizes the Hawthorne effect [59]. Thus, studies should use the simulated patient method to assess the care provided by pharmacists and promote a change in practice.

In the present study, pharmacists and pharmacy team asking more questions than provided counseling on medicine use. Other studies have also shown low percentages of counseling provided by pharmacists and pharmacy team [16, 51]. The literature agrees that pharmaceutical counseling is an essential component of dispensing [11, 62, 63]. The counseling provided by pharmacists during dispensing not only reduces inappropriate use of antimicrobials but also improves treatment adherence and increases patient awareness of the importance of the treatment regimen [64]. Therefore, although certain factors can influence the quantity and quality of pharmaceutical counseling, this intervention must always exist in the drug dispensing.

Among the included studies, medical referral was another intervention performed to encourage patients to attend primary healthcare units. Likewise, a study by Chang et al. [51] also noted that in some cases, referrals were recommended instead of dispensing antimicrobials without prescription. Other studies have reported low rates of intervention and interest in patient health needs [42, 65]. Chowdhury et al. [52] conducted educational interventions aimed at controlling the indiscriminate sale of antimicrobials; the interventions led to fewer referrals and only reduced the dispensing of antimicrobials for children. This evidence raises concerns regarding the attitude adopted by pharmacists and pharmacy teams, as medical referrals can potentially reduce the development of microbial resistance owing to the indiscriminate use of antimicrobials for health conditions that do not require such treatment. Thus, there is an urgent need to encourage a proactive attitude among pharmacists and to combine educational interventions by the pharmacy team and raising awareness about proper antimicrobial use among the general population.

This scoping review revealed that no study has assessed the quality of the antimicrobial dispensing process thus far, highlighting an unmet need. Previous studies have used methods to assess dispensing processes, such as the use of instruments available in the literature [65] and performance assessment sheets constructed by the authors based on guidelines and observation protocols by the authors [66]. Although the identification and measurement of quality services is challenging, quality assessment is imperative to identify problems, deficiencies in the provision of care, and points of improvement, and to delineate strategies to overcome these deficiencies and monitor the effectiveness of corrective measures [67]. Therefore, future studies should invest in the development of quality indicators for antimicrobial dispensing and the development and validation of instruments to assess the quality of dispensing. We also recommend that future studies be conducted to provide evidence for the quality of the antimicrobial dispensing process.

In low- and middle-income countries, we noted that properly trained pharmacists and pharmacy team could be a part of the solution to overcome this global challenge of microbial resistance, and we emphasize that training can improve the role of pharmacy professionals [68]. These issues reinforce the need for pharmacists to continue their education while working in community pharmacies. Our findings highlight the urgency for policymakers to develop multifaceted approaches to qualify for the practice of dispensing antimicrobials. Therefore, there is a need for a patient-focused approach that minimizes the sale of these medicines without prescription.

To address the problem of the indiscriminate use of antimicrobials, multifaceted strategies, including implementing educational and/or regulatory/administrative measurements, promoting changes in cultural practices, and adopting advertising resources with the potential for reinforcement and perpetuation of information that aims educate the population about the risks regarding the indiscriminate use of this class of medicines. Moreover, dispensing practice should be regulated, as it has the potential to mitigate the irrational use of antimicrobials and reduce microbial resistance, in view of the strategic position occupied by community pharmacists and pharmacy teams.

Strengths and limitations

To the best of our knowledge, this scoping review is the first to map and analyze, in the current literature, the range of studies that investigated the dispensing of antimicrobials with and without prescriptions, with a focus on pharmacist interventions. Hence, this study did not use backward or forward snowballing to identify additional relevant studies. There was heterogeneity in the study design, sample, and methods; thus, caution should be exercised when generalizing the results to other health conditions and specific patient populations.

Conclusion

Antimicrobial dispensing processes have mainly been investigated in low- and middle-income countries, with a focus on dispensing antimicrobials without prescriptions. Minimal questions were asked, and patient counseling was below the levels expected of pharmacists and pharmacy team during the dispensing process, identifying a deficiency in the practice. Therefore, improving antimicrobial dispensing processes to promote the rational use of these medicines is necessary. Furthermore, stakeholders should develop multi-faceted strategies to mitigate microbial resistance.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.

Abbreviations

ABs:

Antibiotics

JBI:

Joanna Briggs Institute

MeSH:

Medical subject headings

N/A:

Not applicable

N/R:

Not related

OTC:

Over-the-counter

PCC:

Population-concept-context framework

Presc.:

Prescription

PRISMA:

Preferred reporting items for systematic reviews and meta-analyses

UTI:

Urinary tract infection

References

  1. Da Costa ALP, Silva Junior ACS. Resistência bacteriana aos antibióticos e Saúde Pública: uma breve revisão de literatura. Estação Científica (UNIFAP). 2017;7(2):45.

    Article  Google Scholar 

  2. Klein EY, Van Boeckel TP, Martinez EM, Pant S, Gandra S, Levin SA, et al. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci U S A. 2018;115(15):E3463–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Van Boeckel TP, Gandra S, Ashok A, Caudron Q, Grenfell BT, Levin SA, et al. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis. 2014;14(8):742–50. https://doi.org/10.1016/S1473-3099(14)70780-7.

    Article  PubMed  Google Scholar 

  4. O’Neill J. Tackling drug-resistant infections globally: final report and recommendations. [Internet]. Review on Antimicrobial Resistance. 2016. Available from: https://www.amr-review.org/sites/default/files/160525_Finalpaper_withcover.pdf

  5. SustainAbility. AMR Industry Alliance 2020 Progress Report. 2020;128. Available from: https://www.amrindustryalliance.org/wp-content/uploads/2020/01/AMR-2020-Progress-Report.pdf

  6. Li B, Webster TJ. Bacteria antibiotic resistance: New challenges and opportunities for implant-associated orthopedic infections. J Orthop Res. 2018;36(1):22–32.

    PubMed  Google Scholar 

  7. World Health Organitazion—WHO. Antimicrobial Resistance [Internet]. Newsroom. 2020 [cited 2020 Sep 24]. Available from: https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance

  8. Jamshed S, Padzil F, Shamsudin S, Bux S, Jamaluddin A, Bhagavathula A, et al. Antibiotic stewardship in community pharmacies: a scoping review. Pharmacy. 2018;6(3):92.

    Article  PubMed Central  Google Scholar 

  9. Martins SF, van Mil JWF, da Costa FA. The organizational framework of community pharmacies in Europe. Int J Clin Pharm. 2015;37(5):896–905.

    Article  CAS  PubMed  Google Scholar 

  10. Hernández A, Garcia-Delgado P, Garcia-Cardenas V, Ocaña A, Labrador E, Orera ML, et al. Characterization of patients’ requests and pharmacists’ professional practice in oropharyngeal condition in Spain. Int J Clin Pharm. 2015;37(2):300–9.

    Article  PubMed  Google Scholar 

  11. NHS (National Health Service). Community Pharmacy services—a summary. 2013; Available from: http://psnc.org.uk/wp-content/uploads/2013/08/CPCF-summary-July-2013.pdf

  12. Alkadhimi A, Dawood OT, Hassali MAA. Dispensing of antibiotics in community pharmacy in Iraq: a qualitative study. Pharm Pract (Granada). 2020;18(4):1–9.

    Article  Google Scholar 

  13. Auta A, Hadi MA, Oga E, Adewuyi EO, Abdu-Aguye SN, Adeloye D, et al. Global access to antibiotics without prescription in community pharmacies: a systematic review and meta-analysis. J Infect. 2019;78(1):8–18. https://doi.org/10.1016/j.jinf.2018.07.001.

    Article  PubMed  Google Scholar 

  14. Belachew SA, Hall L, Erku DA, Selvey LA. No prescription? No problem: drivers of non-prescribed sale of antibiotics among community drug retail outlets in low and middle income countries: a systematic review of qualitative studies. BMC Public Health. 2021;21(1):1–13.

    Article  Google Scholar 

  15. Nepal G, Bhatta S. Self-medication with Antibiotics in WHO Southeast Asian Region: a systematic review. Cureus. 2018;10(4).

  16. Batista AD, Rodrigues DA, Figueiras A, Zapata-Cachafeiro M, Roque F, Herdeiro MT. Antibiotic dispensation without a prescription worldwide: a systematic review. Antibiotics. 2020;9(11):1–49.

    Article  CAS  Google Scholar 

  17. Peters MDJ, Marnie C, Tricco AC, Pollock D, Munn Z, Alexander L, et al. Updated methodological guidance for the conduct of scoping reviews. JBI Evid Synth. 2020;18(10):2119–26.

    Article  PubMed  Google Scholar 

  18. Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467–73.

    Article  PubMed  Google Scholar 

  19. Munn Z, Peters MDJ, Stern C, Tufanaru C, McArthur A, Aromataris E. Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Med Res Methodol. 2018;18(1):143.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):1–10. https://doi.org/10.1186/s13643-016-0384-4.

    Article  Google Scholar 

  21. Abdelaziz AI, Tawfik AG, Rabie KA, Omran M, Hussein M, Abou-Ali A, et al. Quality of community pharmacy practice in antibiotic self-medication encounters: a simulated patient study in upper Egypt. Antibiotics. 2019;8(2):35.

    Article  PubMed Central  Google Scholar 

  22. Abubakar U, Tangiisuran B. Knowledge and practices of community pharmacists towards non-prescription dispensing of antibiotics in Northern Nigeria. Int J Clin Pharm. 2020;42(2):756–64. https://doi.org/10.1007/s11096-020-01019-y.

    Article  PubMed  Google Scholar 

  23. Hadi MA, Karami NA, Al-Muwalid AS, Al-Otabi A, Al-Subahi E, Bamomen A, et al. Community pharmacists’ knowledge, attitude, and practices towards dispensing antibiotics without prescription (DAwP): a cross-sectional survey in Makkah Province, Saudi Arabia. Int J Infect Dis. 2016;47:95–100. https://doi.org/10.1016/j.ijid.2016.06.003.

    Article  PubMed  Google Scholar 

  24. Halboup A, Abdi A, Ahmed M, Al-Qadasi F, Othman GQ. Access to antibiotics without prescription in community pharmacies in Yemen during the political conflict. Public Health. 2020;183:30–5. https://doi.org/10.1016/j.puhe.2020.03.003.

    Article  CAS  PubMed  Google Scholar 

  25. Abuirmeileh A, Samara S, Alkhodari A, Bahnassi A, Talhouni A, Hayallah AM. Antibiotic dispensing without prescription in Jordanian community pharmacies: a pharmacist’s perspective. Bull Pharm Sci. 2014;37(June):51–63.

    Google Scholar 

  26. Hallit S, Zahreddine L, Saleh N, Shakaroun S, Lahoud N. Practice of parents and pharmacists regarding antibiotics use in pediatrics: a 2017 cross-sectional study in Lebanese community pharmacies. J Eval Clin Pract. 2020;26(1):181–9.

    Article  PubMed  Google Scholar 

  27. Horumpende PG, Sonda TB, van Zwetselaar M, Antony ML, Tenu FF, Mwanziva CE, et al. Prescription and non-prescription antibiotic dispensing practices in part I and part II pharmacies in Moshi Municipality, Kilimanjaro Region in Tanzania: a simulated clients approach. PLoS ONE. 2018;13(11):1–14.

    Article  CAS  Google Scholar 

  28. Hoxha I, Malaj A, Tako R, Malaj L. Survey on how antibiotics are dispensed in community pharmacies in Albania. Int J Pharm Pharm Sci. 2015;7(7):449–50.

    Google Scholar 

  29. Kalungia AC, Burger J, Godman B, Costa JO, Simuwelu C. Non-prescription sale and dispensing of antibiotics in community pharmacies in Zambia. Expert Rev Anti Infect Ther. 2016;14(12):1215–23.

    Article  CAS  PubMed  Google Scholar 

  30. Koji EM, Gebretekle GB, Tekle TA. Practice of over-the-counter dispensary of antibiotics for childhood illnesses in Addis Ababa, Ethiopia: a simulated patient encounter study. Antimicrob Resist Infect Control. 2019;8(1):4–9.

    Article  Google Scholar 

  31. Llor C, Cots JM. The sale of antibiotics without prescription in pharmacies in Catalonia. Spain Clin Infect Dis. 2009;48(10):1345–9.

    Article  PubMed  Google Scholar 

  32. Mansour O, Al-Kayali R. Community pharmacists’ role in controlling bacterial antibiotic resistance in Aleppo, Syria. Iran J Pharm Res. 2017;16(4):1612–20.

    PubMed  PubMed Central  Google Scholar 

  33. Beaucage K, Lachance-Demers H, Ngo TTT, Vachon C, Lamarre D, Guévin JF, et al. Telephone follow-up of patients receiving antibiotic prescriptions from community pharmacies. Am J Health Pharm. 2006;63(6):557–63.

    Article  Google Scholar 

  34. Nyazema N, Viberg N, Khoza S, Vyas S, Kumaranayake L, Tomson G, et al. Low sale of antibiotics without prescription: a cross-sectional study in Zimbabwean private pharmacies. J Antimicrob Chemother. 2007;59(4):718–26.

    Article  CAS  PubMed  Google Scholar 

  35. Puspitasari HP, Faturrohmah A, Hermansyah A. Do Indonesian community pharmacy workers respond to antibiotics requests appropriately? Trop Med Int Heal. 2011;16(7):840–6.

    Article  CAS  Google Scholar 

  36. Rauber C, Feltrin MR, Piovezan AP. Evaluation of antibiotics dispensing profile in Tubarão, Santa Catarina, Brazil. Braz J Pharm Sci. 2009;45(4):787–93.

    Article  Google Scholar 

  37. Abujheisha KY, Ahmed N. Pharmacists’ Attitudes and Practice Towards: Indo Am J Pharm Sci [Internet]. 2018;05(02):1301–8. Available from: https://zenodo.org/record/1195517

  38. Shet A, Sundaresan S, Forsberg BC. Pharmacy-based dispensing of antimicrobial agents without prescription in India: appropriateness and cost burden in the private sector. Antimicrob Resist Infect Control. 2015;4(1):1–7. https://doi.org/10.1186/s13756-015-0098-8.

    Article  Google Scholar 

  39. Shi L, Chang J, Liu X, Zhai P, Hu S, Li P, et al. Dispensing antibiotics without a prescription for acute cough associated with common cold at community pharmacies in Shenyang, Northeastern China: a cross-sectional study. Antibiotics. 2020;9(4).

  40. Yaacoub SG, Lahoud NA, Francis NJ, Rahme DW, Murr TH, Maison PF, et al. Antibiotic prescribing rate in Lebanese community pharmacies: a nationwide patient-simulated study of acute bacterial rhinosinusitis. J Epidemiol Glob Health. 2019;9(1):44–9.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Zawahir S, Lekamwasam S, Aslani P. Antibiotic dispensing practice in community pharmacies: a simulated client study. Res Soc Adm Pharm. 2018;15(5):584–90. https://doi.org/10.1016/j.sapharm.2018.07.019.

    Article  Google Scholar 

  42. Zawahir S, Lekamwasam S, Aslani P. Community pharmacy staff’s response to symptoms of common infections: a pseudo-patient study. Antimicrob Resist Infect Control. 2019;8(1):1–10.

    Article  Google Scholar 

  43. Alabid AHMA, Ibrahim MIM, Hassali MA. Antibiotics dispensing for URTIs by community pharmacists and general medical practitioners in Penang, Malaysia: a comparative study using simulated patients. J Clin Diagn Res. 2014;8(1):119–23.

    PubMed  PubMed Central  Google Scholar 

  44. Bin Abdulhak AA, Altannir MA, Almansor MA, Almohaya MS, Onazi AS, Marei MA, et al. Non prescribed sale of antibiotics in Riyadh, Saudi Arabia: a cross sectional study. BMC Public Health. 2011;11(1):538.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Almaaytah A, Mukattash TL, Hajaj J. Dispensing of non-prescribed antibiotics in Jordan. Patient Prefer Adherence. 2015;9:1389–95.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Al-Tannir M, Altannir Y, Altannir M, AlFayyad I. Community pharmacy sales of non-prescribed antibiotics in Riyadh, Saudi Arabia: a simulated patient study. Int J Clin Pharm. 2020;42(2):341–6. https://doi.org/10.1007/s11096-020-01033-0.

    Article  PubMed  Google Scholar 

  47. Amirthalingam S, Verma RK, Appalasamy JR, Barura A, Yi KS. Pharmacists’ knowledge and perception of topical antibacterial drug dispensing in community pharmacy setting in Kedah, Malaysia. Trop J Pharm Res. 2016;15(4):855–60.

    Article  Google Scholar 

  48. Bahnassi A. Pharmacists views and practices in regard to sales of antibiotics without a prescription in Madinah, Saudi Arabia. J Patient Saf. 2014;12(3):159–64.

    Article  Google Scholar 

  49. Bahnassi A. A qualitative analysis of pharmacists’ attitudes and practices regarding the sale of antibiotics without prescription in Syria. J Taibah Univ Med Sci. 2015;10(2):227–33. https://doi.org/10.1016/j.jtumed.2014.09.001.

    Article  Google Scholar 

  50. Chang J, Ye D, Lv B, Jiang M, Zhu S, Yan K, et al. Sale of antibiotics without a prescription at community pharmacies in urban China: a multicentre cross-sectional survey. J Antimicrob Chemother. 2017;72(4):1235–42.

    CAS  PubMed  Google Scholar 

  51. Chang J, Xu S, Zhu S, Li Z, Yu J, Zhang Y, et al. Assessment of non-prescription antibiotic dispensing at community pharmacies in China with simulated clients: a mixed cross-sectional and longitudinal study. Lancet Infect Dis. 2019;19(12):1345–54. https://doi.org/10.1016/S1473-3099(19)30324-X.

    Article  PubMed  Google Scholar 

  52. Chowdhury F, Sturm-Ramirez K, Al Mamun A, Iuliano AD, Chisti MJ, Ahmed M, et al. Effectiveness of an educational intervention to improve antibiotic dispensing practices for acute respiratory illness among drug sellers in pharmacies, a pilot study in Bangladesh. BMC Health Serv Res. 2018;18(1):1–11.

    Article  Google Scholar 

  53. Contopoulos-Ioannidis DG, Koliofoti ID, Koutroumpa IC, Giannakakis IA, Ioannidis JPA. Pathways for inappropriate dispensing of antibiotics for rhinosinusitis: a randomized trial. Clin Infect Dis. 2001;33(1):76–82.

    Article  CAS  PubMed  Google Scholar 

  54. Erku DA, Aberra SY. Non-prescribed sale of antibiotics for acute childhood diarrhea and upper respiratory tract infection in community pharmacies: a 2 phase mixed-methods study. Antimicrob Resist Infect Control. 2018;7(1):1–7.

    Article  Google Scholar 

  55. Guinovart MC, Figueras A, Llor C. Selling antimicrobials without prescription • Far beyond an administrative problem. Enfermedades Infecc y Microbiol Clin (English ed). 2018;36(5):290–2. https://doi.org/10.1016/j.eimce.2016.10.005

  56. Afari-Asiedu S, Oppong FB, Tostmann A, Ali Abdulai M, Boamah-Kaali E, Gyaase S, et al. Determinants of inappropriate antibiotics use in rural central Ghana using a mixed methods approach. Front Public Health. 2020;8(March):1–11.

    Google Scholar 

  57. Nguyen HH, Ho DP, Vu TLH, Tran KT, Do Tran T, Nguyen TKC, et al. “I can make more from selling medicine when breaking the rules”—understanding the antibiotic supply network in a rural community in Viet Nam. BMC Public Health. 2019;19(1):1–11.

    Article  CAS  Google Scholar 

  58. Okereke M, Ukor NA, Adebisi YA, Ogunkola IO, Favour Iyagbaye E, Adiela Owhor G, et al. Impact of COVID-19 on access to healthcare in low- and middle-income countries: current evidence and future recommendations. Int J Health Plan Manag. 2021;36(1):13–7.

    Article  Google Scholar 

  59. Björnsdottir I, Granas AG, Bradley A, Norris P. A systematic review of the use of simulated patient methodology in pharmacy practice research from 2006 to 2016. Int J Pharm Pract. 2020;28(1):13–25.

    Article  PubMed  Google Scholar 

  60. Watson MC, Norris P, Granas AG. A systematic review of the use of simulated patients and pharmacy practice research. Int J Pharm Pract. 2006;14(2):83–93.

    Article  Google Scholar 

  61. Collins JC, Chong WW, de Almeida Neto AC, Moles RJ, Schneider CR. The simulated patient method: design and application in health services research. Res Soc Adm Pharm. 2021;17(12):2108–15. https://doi.org/10.1016/j.sapharm.2021.04.021.

    Article  Google Scholar 

  62. Cerqueira-Santos S, Rocha KSS, Boaventura TC, Jesus EMS, Silvestre CC, Alves BMCS, et al. Development and content validation of an instrument to document the dispensing of prescribed medicines. J Clin Pharm Ther. 2019;44(3):430–9.

    Article  PubMed  Google Scholar 

  63. Rocha KSS, Cerqueira Santos S, Boaventura TC, dos Santos Júnior GA, de Araújo DCSA, Silvestre CC, et al. Development and content validation of an instrument to support pharmaceutical counselling for dispensing of prescribed medicines. J Eval Clin Pract. 2020;26(1):134–41.

    Article  PubMed  Google Scholar 

  64. Akbar Z, Saleem Z, Shaukat A, Farrukh MJ. Perception and practices of community pharmacists towards antimicrobial stewardship in Lahore, Pakistan. J Glob Antimicrob Resist. 2021;25:157–61. https://doi.org/10.1016/j.jgar.2021.03.013.

    Article  CAS  PubMed  Google Scholar 

  65. Mesquita AR, De Oliveira Sá DAB, Santos APAL, De Almeida NA, Lyra DP. Assessment of pharmacist’s recommendation of non-prescription medicines in Brazil: a simulated patient study. Int J Clin Pharm. 2013;35(4):647–55.

    Article  PubMed  Google Scholar 

  66. Obreli-Neto PR, Pereira LRL, Guidoni CM, De Baldoni AO, Marusic S, De Lyra DP, et al. Use of simulated patients to evaluate combined oral contraceptive dispensing practices of community pharmacists. PLoS ONE. 2013;8(12):1–9.

    Article  Google Scholar 

  67. Watson MC, Skea ZC. Jugglers and tightrope walkers: the challenge of delivering quality community pharmacy services. PLoS ONE. 2018;13(7):1–15.

    Article  CAS  Google Scholar 

  68. Sakeena MHF, Bennett AAMA. Reinforcing the role of pharmacists in developing countries to overcome the challenge of antimicrobial resistance: a narrative review. Antimicrob Resist Infect Control. 2018;7(1):63.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We thank Rafaella de Oliveira Santos Silva for her assistance with the Ryyan tool.

Funding

This study was financed in part by the “Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.” The funder had no role in the design of the study; collection, analysis, and interpretation of data; or in writing the manuscript.

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Authors and Affiliations

  1. Graduate Program in Pharmaceutical Sciences, Laboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, Avenue Marechal Rondon, Jd. Rosa Elze, São Cristóvão, Sergipe State, 49100-000, Brazil

    Elindayane Vieira de Souza & Sabrina Cerqueira-Santos

  2. Laboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, Avenue Marechal Rondon, Jd. Rosa Elze, São Cristóvão, Sergipe State, 49100-000, Brazil

    Lara Joana Santos Caxico Vieira, Sylmara Nayara Pereira dos Santos & Divaldo Pereira de Lyra Jr

  3. Health Sciences Graduate Program, Laboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, Avenue Marechal Rondon, Jd. Rosa Elze, São Cristóvão, Sergipe State, 49100-000, Brazil

    Kérilin Stancine Santos Rocha

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  1. Elindayane Vieira de Souza
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  2. Lara Joana Santos Caxico Vieira
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  6. Divaldo Pereira de Lyra Jr
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Contributions

EVS, SCS, KSSR, and DPLJ made substantial contributions to the conception and design of this study. EVS, LJSCV, and SNPS acquired, analyzed, and interpreted the data. EVS and LJSCV drafted the manuscript KSSR, SCS, and DPLJ reviewed and made important contributions to the structure and content of the manuscript. All authors have accepted the final version of the manuscript.

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Correspondence to Divaldo Pereira de Lyra Jr.

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Supplementary Information

Additional file 1.

Database search strategy.

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de Souza, E.V., Vieira, L.J.S.C., dos Santos, S.N.P. et al. Antimicrobial dispensing process in community pharmacies: a scoping review. Antimicrob Resist Infect Control 11, 116 (2022). https://doi.org/10.1186/s13756-022-01157-0

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Keywords

  • Antimicrobials
  • Dispensing
  • Community pharmacy
  • Pharmacists

Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

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