- Open Access
Intrinsic and external determinants of antibiotic prescribing: a multi-level path analysis of primary care prescriptions in Hubei, China
Antimicrobial Resistance & Infection Control volume 8, Article number: 132 (2019)
Irrational use of antibiotics is a major driver of development of antibiotic resistance, which heavily threatens population health worldwide. Understanding the mechanism of physician’s antibiotic prescribing decisions is increasingly highlighted to promote prudent use of antibiotics. Therefore, the current study aimed to fill the gap, modelling physician’s antibiotic prescribing and identifying the potential intrinsic and external determinants of antibiotic prescribing in primary care.
A total of 428,475 prescriptions from 499 prescribers in 65 primary care facilities in Hubei of China were audited. Teixeira Antibiotic Prescribing Behavioral Model (TAPBM) was referred as theoretical basis to identify intrinsic and external predictors of antibiotic prescriptions. A questionnaire survey was conducted, covering potential physician’s intrinsic determinants (knowledge, attitudes and individual characteristics) and external factors both in individual level (patient pressure, time pressure and financial incentives) and institutional level (setting and local socio-economic development). A two-level path analysis was performed linking potential determinants of antibiotic use with physician’s actual practices.
About 44.28% of the prescriptions contained antibiotics, with 9.28% containing two or more antibiotics. The multi-level path analysis revealed that knowledge was a significant predictor of attitudes (β = 0.154, p < 0.05), but higher knowledge and attitudes failed to translate into antibiotic prescribing practices ((β = − 0.076 – 0.039, p > 0.05). Instead, external factors played a more important role and physician’s antibiotic use was significantly associated with patient pressure (β = 0.102, p = 0.022), time pressure (β = − 0.164, p = 0.002), financial incentives (β = − 0.133– − 0.155, p = 0.027) and institutional environments (rural area, β = 0.408, p = 0.002; and high socioeconomic setting, β = − 0.641 - -0.578, p < 0.001 ). The prescribers who were male (β = − 0.168, p = 0.007) or had lower qualification (β = − 0.114, p = 0.028) were also more likely to prescribe antibiotics than others.
Antibiotic prescribing practices are complex process and associated with both intrinsic (prescriber) and external (patients and institutional environment) factors. A systematic approach is required to curb over-prescription of antibiotics. Apart from educating prescribers, it is equally important, if not more, to educate patients, break incentives and nurture professional culture within organization to reduce the overuse of antibiotics.
Antibiotic resistance (AR), one of the most serious public health issues, threatens population health and socioeconomic development of all nations over the world . It not only jeopardizes our ability to prevent and treat microbial infections, but also put many common medical procedures (e.g. caesarean sections) potentially fatal again, for which antibiotics are commonly used to prevent potential infections. It was projected that AR will contribute to 10 million deaths in 2050 if no effective actions are taken, surpassing cancer and becoming the leading cause of death .
Irrational use of antibiotics is a major driver fueling the development of AR [3, 4]. Promoting prudent antibiotic use is considered as a core measure to address this global threat . For patients, antibiotics are commonly prescription-required medicines. Therefore, rational prescribing from physicians plays a fundamental role for prudent use of antibiotics . Unfortunately, inappropriate and over prescriptions of antibiotics are prevalent worldwide. For example, 30% of antibiotic prescriptions in outpatient care in the US were deemed unnecessary . In China, this figure was estimated to be as high as 60% .
Many studies have attempted to understand how and why physicians prescribe antibiotics irrationally [8, 9]. Knowledge and attitudes are perhaps the most frequently explored predictors of antibiotic prescribing [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24]. These studies often suffered from some common methodological limitations. For example, they examined the theoretical knowledge of physicians and their intended use of antibiotics for simulated cases [9, 21]. However, prescribing practices are subject to the influence of a much broader range of factors. Our understanding on actual antibiotic prescribing practices is still limited [8, 9, 25].
Teixeira suggested a comprehensive framework for studying prescribing practices . It considers the influence of both intrinsic factors (e.g. knowledge and attitudes of prescribers) and external factors (e.g. requests from patients, employers and governments) on prescribing practices. The Teixeira Antibiotic Prescribing Behavioral Model (TAPBM) also tries to explain the complicated connections among multiple factors, which may involve precedence or compromise.
Although the TAPBM has been widely endorsed by the research community , there is a lack of empirical studies testing the model, possibly due to difficulties to link different sources of data. This study aimed to test the TAPBM through linking the survey data of prescribers to their prescriptions. The findings will contribute to the existing debate on determinants of antibiotic prescribing practices, filling the gap in the literature.
This study was conducted in Hubei, a province in central China covering a land of 185.9 thousand km2 and 59.02 million populations. Hubei had a gross domestic product (GDP) of $8915 per capita in 2017, ranking at number 11 among all (34) provinces in China. It is classified as a middle-high income region based on the criteria of the World Bank .
The study setting was restricted to primary care facilities, which included both urban community health centers (UCHCs) and rural township health centers (RTHCs). In 2017, Hubei had 347 UCHCs and 1137 RTHCs, receiving 23.03 million and 56.00 million outpatient visits, respectively . Over-prescription of antibiotics was prevalent in these facilities: 65% of prescriptions contained antibiotics and 20% involved two or more antibiotics .
This study adopted the TAPBM as an overarching framework. The TAPBM extended the widely-accepted Knowledge-Attitudes-Practices (KAP) theory and included considerations of external determinants of antibiotic prescribing practices .
Intrinsic determinants: knowledge and attitudes are the core of intrinsic determinants of antibiotic prescribing practices. Knowledge can influence prescribing behaviors directly or indirectly through influencing attitudes . The knowledge and attitudes of prescribers can be shaped by many individual characteristics [8, 9], such as gender, qualifications, clinical expertise, continuing education, and years of practices.
External determinants: when physicians prescribe medicines, they are likely to take considerations of many external factors apart from relevant clinical standards and guidelines. Pressures from patients, peers, employers, governments, and the public may sway antibiotic prescribing decisions. These factors can exert impacts on prescribing practices directly or indirectly through influencing attitudes .
Previous studies showed that patient requests for antibiotics increased antibiotic prescribing dramatically, especially when the physicians felt that they did not have enough time to explain details to their patients [28, 29]. It has been well documented that financial incentives can also drive antibiotic prescribing in primary care in China. Such perverse incentives are particularly strong for the physicians with a lower household income .
Formal and informal institutional and system arrangements also play an important role in shaping prescribing decisions. Several studies in the European countries showed that antibiotic prescribing practices are associated with the culture of an organization (shared values and behaviors among employees) [31, 32] and the culture of a nation (e.g. tolerance of uncertainty and status distinction) . Empirical evidence in China showed that over-prescription of antibiotics is more prevalent in primary care facilities in rural  and socioeconomically disadvantaged regions [34, 35] compared with those in urban and better-off regions.
In this study, the TAPBM framework was adapted considering the availability of relevant data and measurements. We adopted a two-level modelling approach, covering the effects of individual (physician) factors and institutional (cluster-level) factors. The individual-level measurements included both intrinsic (e.g. characteristics of prescribers) and external (e.g. perceived pressures) indicators. The institutional-level measurements were represented by two proxy indicators: urban/rural location and socioeconomic status of the servicing community (Fig. 1). We chose a two-level model for two reasons. First, a cluster sampling strategy was adopted to select study participants. Second, cluster effects were significant as measured by the intra-cluster correlation coefficient (ICC): 0.004 for knowledge, 0.094 for attitudes, and 0.395–0.408 for antibiotic prescribing practices. Institutional variations in individual knowledge, attitudes and prescribing practices were deemed random (depicted using a black dot in Fig. 1), and their random intercepts were predicted by the two institutional indicators.
Two indicators were calculated to measure antibiotic prescribing practices in line with the World Health Organization (WHO) recommendations :
Percentage of prescriptions containing antibiotics = Number of prescriptions containing antibiotics / Total prescriptions × 100%;
Percentage of prescriptions with combined use of antibiotics = Number of prescriptions containing two or more antibiotics / Total prescriptions × 100%;
Predictors of outcome measures
Individual-level intrinsic factors
Knowledge: Antibiotic prescribing knowledge was measured with 11 items that were commonly used in previous studies [13, 22, 37], asking the physician respondents to make a prescribing decision under various scenarios, such as for patients with non-febrile diarrhea, upper respiratory tract infections, methicillin resistant staphylococcus, and bacterial pneumonia. Each scenario was provided with 4 or 5 prescribing options, with only one correct answer. An “unknown” option was also listed to discourage guessing. A summed score of knowledge about antibiotic prescribing was calculated, ranging from 0 to 11. A higher score indicates better knowledge.
Attitudes: Attitudes of the physician respondents were measured using the 11-item Knowledge and Attitudes regarding Antibiotics and Resistance (KAAR-11) scale, which has been fully validated in previous studies . The KAAR-11 asked respondents to rate their opinions on a four-point Likert scale (ranging from 0 “totally agree” to 4 “totally disagree”) about the excuses for irrational prescriptions of antibiotics, such as satisfying patient requests, avoiding patient complaints, ignoring or blaming others for AR. A summed score of KAAR-11 was calculated, ranging from 0 to 44. A higher score indicates a more favorable attitude to rational prescribing of antibiotics .
Individual characteristics of prescribers: These included the demographic characteristics (gender and education) and the professional experiences (years of clinical practices, professional title, and training on antibiotic prescriptions) of the participants. All of the physician respondents were general practitioners. Therefore, clinical expertise was excluded in the analysis.
Individual-level external factors
Perceived patient pressure: Respondents were asked “how many percent of patients you see expect antibiotic prescriptions” and “how often the patient expectation influences your decision of antibiotic prescribing”. The latter was rated on a five-point Likert scale ranging from “1 = always” to “0 = never”. Scores of the two questions were multiplied as an indication of patient pressure (ranging from 0 to 100).
Time pressure: Respondents were asked to estimate the average duration (minutes) of consultations for each patient visit, with a lower duration indicating higher time pressure.
Household income: Respondents were asked to estimate their annual household income (Chinese Yuan ¥) over the previous year. The household income was classified into four categories: < 40,000; 40,000-79,999; 80,000-119,999; ≥120,000.
The characteristics of the participating primary care institutions were measured with two indicators: rural/urban location and socioeconomic status of the servicing community. All of the participating primary care facilities were public institutions governed by the same policy and regulatory framework. The socioeconomic status was classified based on GDP per capita of their local districts: high (top four districts) vs low.
The questionnaire was pilot tested in 23 physicians from 3 primary care facilities. They were asked to explain why they chose or did not choose certain answers. The feedback was used to modify the questionnaire. Of the 30 tested questionnaire items, 9 were rephrased and no items were deleted or added (the final instrument could be found in the Additional file 1: Table S1).
Sampling and data collection
A stratified cluster sampling strategy was adopted to select study participants. A total of 65 primary care facilities were randomly selected from 3 urban and 6 rural districts corresponding to the distribution of primary care facilities in Hubei. The participating primary care institutions represented 5.5% (19/347) of UCHCs and 4.1% (46/1137) of RTHCs, respectively. Details about the sampling approach have been published elsewhere .
The physicians who prescribed antibiotics independently in the participating primary care facilities were eligible for this study. To minimize bias, only those who prescribed ≥100 prescriptions three months prior to the commencement of the questionnaire survey of prescribers were invited to participate in this study.
Extraction of prescription data
Prescription data from January 1st to March 31st, 2018 were extracted either from the participating primary care institutions or from the medical administration system of the local governments. These included the name of the institution, the ID number of the prescriber, patient ID, date of the prescription, and the type, volume and price of the medicines prescribed.
A questionnaire survey of prescribers in the participating primary care institutions was conducted from April 23rd to June 6th, 2018. A pair of trained investigators visited each primary care facility and invited all of the physicians working at the time to complete the questionnaire. An informed written consent was obtained before the respondents self-completed the questionnaire. The survey took about 15 min. Completed questionnaires were returned to the investigators immediately. The investigators examined the completeness of the returned questionnaires. Missing items, if existed, were re-filled through a supplementary interview. A token gift ($1.65) was given to the participants.
In total, 712 physicians agreed to participate in the survey, representing 93.44% of all physicians in the participating institutions. About 664 complete questionnaires were returned, of which 499 met the inclusion criteria and passed logic check. This resulted in an effective response rate of 70.08%.
The prescription outcome indicators were calculated from the extracted prescription database and then mapped into the questionnaire survey data in line with the ID number of the prescribers. The two institutional variables were obtained from the classification system of the statistics bureau of Hubei government and mapped into the questionnaire data in line with the name of the institutions.
We compared the differences of respondents between the urban and rural settings, using Chi-square (or Fisher’s exact) tests for binary variables, Wilcoxon rank-sum tests for continuous variable without a normal distribution, and Student t tests for continuous variables with a normal distribution.
A two-level path analysis was performed to test the TAPBM using a mixed effect model. Institutional variations in the individual knowledge, attitudes and prescribing practices were treated as a random effect, with the random intercepts being further predicted by the institutional (cluster-level) variables. The analysis adopted the maximum likelihood with robust standard error (MLR) estimation, which can be applied for variables without a normal distribution. The fitness of data into the model was assessed using three criteria [40, 41]: RMSEA< 0.08, CFI > 0.95, and SRMR< 0.08.
The statistical analyses were performed using STATA (version 12.0) and Mplus (version 6.0). A p value < 0.05 was considered statistically significant.
Characteristics of survey respondents
About 21.64% of respondents worked in the UCHCs. Over half of the UCHC respondents were women compared with only 23.53% in the RTHCs (p < 0.001). Compared with the UCHC respondents, those from the RTHCs were younger, had lower qualifications, lower professional titles, shorter experiences in clinical practices, and lower household income (Table 1). Over three quarters (78.76%) of the RTCH respondents attended training programs on antibiotic prescribing in 2017, compared with 62.96% of respondents from the UCHCs (p = 0.001).
Antibiotic prescribing practices
The study participants prescribed 428,475 prescriptions over the three-month period: 44.28% (189,719) contained antibiotics and 9.28% (39,778) contained two or more antibiotics. Those from the RTHCs were more likely to prescribe antibiotics than their UCHC counterparts. But the differences were only statistically significant in the combined use of antibiotics (p < 0.001) (Table 2).
The respondents had a mean knowledge score of 6.11 (SD = 1.46) about rational antibiotic prescriptions. The percentage of respondents giving a correct prescribing answer was very low: 5.01% for upper respiratory tract infections, 11.22% for renal failure, 29.06% for methicillin resistant staphylococcus, 46.49% for bacterial pneumonia, and 41.28% for antibiotic treatments crossing the blood-brain barrier. No overall knowledge difference appeared between the UCHC and RTHC respondents (p = 0.073), although those from the UCHCs were more likely to give a correct answer to antibiotic prescriptions for anaerobes (p = 0.048) and to the standards of antibiotic use in primary care (p = 0.003).
The respondents had a mean KAAR-11 score of 27.56 (SD = 3.46). Compared with the UCHC respondents, those from the RTHCs were more likely to recognize AR as a public health problem (p = 0.006), but blame others for the development of AR (p = 0.017), and prescribe antibiotics for defensive purpose (p < 0.05).
The study participants perceived high levels of patient pressure on antibiotic prescribing. On average, over half (54.91%) of the patients were reported to have an expectation on antibiotic prescriptions. This resulted in a mean patient pressure score of 25.63% (SD = 21.41%) weighted by perceived influence of patient requests. The RTHC physicians perceived higher patient expectations (p = 0.001) and greater impacts of patient pressure (p = 0.026) compared with their UCHC counterparts.
On average, the physician respondents spent 10.58 min (SD = 6.47) for each patient consultation. The length of patient consultation was longer in the UCHCs than in the RTHCs (p = 0.007), indicating a lower time pressure.
Determinants of antibiotic prescribing behaviors
A good fitness of the data into the TAPBM model (Fig. 2) was evident: RMSEA = 0.037 (< 0.08), CFI = 0.994 (> 0.95), SRMR< 0.08 at both individual and cluster levels.
Intrinsic factors: individual knowledge and attitudes did not predict antibiotic prescribing practices (β: − 0.076–0.039, p > 0.05), although better knowledge was associated with positive attitudes toward rational use of antibiotics (β = 0.154, p = 0.001). Female physicians were less likely to prescribe antibiotics (β = − 0.168, p = 0.007) but more likely to use two or more antibiotics (β = 0.194, p < 0.001) compared with their male counterparts. Higher qualifications were associated with less prescriptions of antibiotics (β = − 0.114, p = 0.028). Professional title, experience of clinical practices, and continuing education were not significant predictors (p > 0.05) on knowledge, attitudes and practices in antibiotic prescribing (omitted in Fig. 2).
External factors: perceived higher patient pressure was associated with negative attitudes towards rational use of antibiotics (β = − 0.165, p < 0.001) and higher use of antibiotics (β = 0.102, p = 0.022). Higher time pressure was associated with higher use of antibiotics (β = − 0.164, p = 0.002), although it failed to predict attitudes toward rational use of antibiotic (β = − 0.091, p > 0.05). Higher household income was associated with lower use of antibiotics (β = − 0.133, p = 0.027) and lower combined use of antibiotics (β = − 0.155, p = 0.012).
At the cluster-level, rural location was a significant predictor of higher use of antibiotics (β = 0.408, p = 0.002). The facilities servicing communities with a higher socioeconomic status were less likely to prescribe antibiotics (β = − 0.641, p < 0.001) and less likely to use combined antibiotics (β = − 0.578, p < 0.001). The institutional variables did not predict the knowledge and attitudes of physicians (p > 0.05).
This study confirmed that antibiotic prescribing practices involve complex mechanisms and the TAPBM can be used for exploring determinants of antibiotic prescriptions, including both intrinsic and external factors at the individual and institutional levels.
High levels of antibiotic prescriptions are evident in primary care in Hubei: 44.28% involved at least one antibiotic. Although this represents a decline of antibiotic prescriptions in general , it is still much higher than what has been recommended by the Chinese government (20%) and the World Health Organization (30%) . In this study, the physicians demonstrated poor knowledge about antibiotic prescribing. Although poor knowledge does not predict antibiotic prescribing directly, it may leave greater opportunities for external factors to sway prescribing decisions. We found that time pressure and patient requests are associated with higher levels of antibiotic prescriptions. Antibiotic prescribing practices are also associated with individual characteristics (gender, education and income) of physicians and institutional environments (location and socioeconomic status).
Strengths and weaknesses of the study
This study tested both intrinsic and external determinants of antibiotic prescribing through a two-level path analysis based on the TAPBM. Such an approach allowed us to examine antibiotic prescribing practices in a comprehensive and systematic way, tapping into factors associated with prescribers, patients, and institutional environments . We were able to link prescribing data with survey data on prescribers, which has commonly been absent in previous studies [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24]. We also adopted well-validated instruments for measuring knowledge and attitudes of physicians, addressing problems embedded in some previous studies .
There are several limitations in this study. Firstly, this study was conducted in Hubei, a middle-high income region. Generalization of the findings of this study to other regions should be cautious. Secondly, in this study, prescribing indicators were not risk-adjusted due to unavailability of data regarding patient conditions. Thirdly, there is a consensus that the pharmaceutical industry may play an important role in driving prescribing decisions of physicians. The Chinese government has attempted to delink financial incentives associated with prescribing practices. However, measuring such links is difficult, if not impossible. We could only use household income as a proxy indicator in this study. Finally, there is large standard deviation of some parameters in current study, indicating a huge difference in physician’s knowledge, attitudes and practices. The situation may imply that several latent classes of physicians, and among which a specific group of physicians with poorer knowledge and attitudes may play an important role contributing to the high irrational prescribing of antibiotics. However, the analysis is out of reach of the current study and further studies are warranted.
Comparison to other studies
Effects of intrinsic factors
Knowledge and attitudes may play different roles in prescribing practices under different system contexts. This study found no direct links between “knowledge and attitudes” and antibiotic prescribing practices, similar to the findings of a study of general practitioners (GPs) in Scotland . But in Spain, appropriate use of antibiotics in clinical practices was found to be closed associated with the specific knowledge and attitudes of primary care physicians .
Clearly, interventions targeting prescribers alone on their knowledge and attitudes are not enough to curb over-prescriptions of antibiotics. In another study using the theory of planned behavior, we also found that antibiotic prescribing is not under the volitional control of physicians .
Individual characteristics of prescribers can shape antibiotic prescribing practices. Several studies revealed that female physicians are less likely to prescribe antibiotics [44, 45], consistent with the findings of this study. But female prescribers are more likely to combine antibiotics when they prescribe antibiotics. Roter and colleagues concluded in a systematic review that such a prescribing style is likely to be associated with the more patient-centered communication style of female physicians . Female prescribers found it easier to implement the “wait-and-see” policy on antibiotic prescribing but harder to refuse patient requests compared with their male counterparts .
Higher medical qualifications were found to be associated with less antibiotic prescriptions in this study after adjustments of knowledge levels. This may be attributable to the professional culture. Formal and systematic medical training may boost the confidence of practitioners  and encourage physicians to consider a greater variety of interventional strategies .
Effects of external factors
It appears that external factors play a more important role in predicting antibiotic prescribing. Similar to findings of other studies [25, 49,50,51,52], this study revealed that patient pressure is a major driver of antibiotic prescriptions. In China, defensive clinical practices are common . The poor health literacy of consumers and a lack of trust in medical service providers is often blamed for fueling over-prescriptions of antibiotics.
There is no direct evidence in this study to prove that antibiotic prescribing practices are associated with financial incentives. However, low household income of physicians was found to be associated with high antibiotic prescriptions. Such a link was also documented in some previous studies . Despite a significant increase in governmental investment on primary care in China, two-thirds of the budget of primary care facilities still needs to be recovered by service revenues . This may motivate primary care physicians to seek extra income through over-provision of services.
The institutional variations in antibiotic prescribing practices are concerning. Rural health facilities and those servicing communities with a low socioeconomic status are relatively poorly resourced. But they are more likely to prescribe antibiotics than their better-off counterparts. China is not alone. Similar phenomena were also observed in Italy , Switzerland  and Germany . This has significant implications on the effective use of the already scant health resources in the worse-off communities .
Policy interventions targeting external factors associated with antibiotic prescribing are essential. Although medical education by itself is important , it can only be adopted as a long term strategy. The current focus and investment on continuing education  and development of clinical guidelines  will have limited effects if external determinants of antibiotic prescribing are not properly addressed [7, 35, 61, 62].
To address the external determinants revealed in this study, several interventional strategies should be highlighted according to the empirical evidence published in the literature:
(1) Better communication skills and “wait-and-see” approach may help physicians to deal with patient pressure for antibiotics [63,64,65]. A study in Guangxi of China confirmed the value of communication training programs in reducing antibiotic prescriptions in pediatric care .
(2) Patients can be educated through social marketing campaigns to improve their understanding on the use of antibiotics and subsequently reduce requests for antibiotics . However, it is challenging to change the public stereotype of antibiotics as panacea. Some pilot trials in patient education using leaflets  or public reporting  have demonstrated limited efforts in China.
(3) There is a need to improve governance and management competencies in primary care. The funding system should encourage prescribers to make decisions based on the clinical conditions of their patients, not financial gains [69, 70]. A professional culture needs to be nurtured. Empirical evidence shows that antibiotic prescribing decisions are often influenced by peers. Antibiotic prescribing can be significantly reduced when a prescriber perceives her/himself as an outlier compared with colleagues .
Antibiotic prescribing is a complex process shaped by both intrinsic (knowledge, attitudes and individual characteristics) and external (patients, institutions and healthcare systems) factors. A systems approach is required to curb over-prescription of antibiotics in China. Apart from educating prescribers, it is equally important, if not more, to educate patients to ease the pressure from patient requests. Management also plays an important role in changing prescribing behaviors.
The link between high use of antibiotics and low socioeconomic status is concerning. Further studies are warranted to explore the underlying reasons of higher antibiotic use in rural and low socioeconomic settings in China.
Availability of data and materials
The data that support the findings of this study are available from surveyed local institutions and governments but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request and with permission of surveyed local institutions and governments.
comparative fit index
Gross domestic product
Intra-cluster correlation coefficient
11-item Knowledge and Attitudes regarding Antibiotics and Resistance
Maximum likelihood with robust standard error
Root mean square error of approximation
Rural township health centers
Structural equation modelling;
Standardized root mean squared residual
Teixeira Antibiotic Prescribing Behavioral Model
Urban community health centers
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The authors would like to sincerely thank the participating physicians and the support from managers of the included institutions and local governments.
This study was funded by the National Natural Science Foundation of China (grant no. 71373092).
The funding body played no part in the study design, collection, analysis and interpretation of data, writing of the manuscript or the decision to submit the manuscript for publication.
Ethics approval and consent to participate
This study was approved by the Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology (NO: IORG 0003571).
Written consent was obtained from each participant in current study.
Consent for publication
Written consent for publication was obtained from each participant prior to the survey.
The authors declare no conflict of interest.
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