WHO. Report on the endemic burden of healthcare-associated infection Worldwide. World Health Organization; 2011.
WHO guidelines on hand hygiene in health care: First global patient safety challenge clean care is safer care. 2009.
O’Neill J. Antimicrobial resistance antimicrobial resistance: tackling a crisis for the health and wealth of nations. mSystems. 2014;6:e0036021.
Buetti N, Wassilew N, Rion V, Senn L, Gardiol C, Widmer A, et al. Emergence of vancomycin-resistant enterococci in Switzerland: a nation-wide survey. Antimicrob Resist Infect Control. 2019;8:16.
Thierfelder C, Keller PM, Kocher C, Gaudenz R, Hombach M, Bloemberg GV, et al. Vancomycin-resistant enterococcus. Swiss Med Wkly. 2012;142:w13540.
Widmer AF. Vancomycin-resistant enterococci: an ongoing challenge for infection control. Swiss Med Wkly. 2012;142:w13554.
Pittet D, Allegranzi B, Sax H, Dharan S, Pessoa-Silva CL, Donaldson L, et al. Evidence-based model for hand transmission during patient care and the role of improved practices. Lancet Infect Dis. 2006;6(10):641–52.
Sax H, Allegranzi B, Uçkay I, Larson E, Boyce J, Pittet D. “My five moments for hand hygiene”: a user-centred design approach to understand, train, monitor and report hand hygiene. J Hosp Infect. 2007;67(1):9–21.
Gould DJ, Moralejo D, Drey N, Chudleigh JH. Interventions to improve hand hygiene compliance in patient care. Cochrane Database Syst Rev. 2010;9:CD005186.
Clack L, Scotoni M, Wolfensberger A, Sax H. “First-person view” of pathogen transmission and hand hygiene—use of a new head-mounted video capture and coding tool. Antimicrob Resist Infect Control. 2017;6:108.
Otter JA, Yezli S, Salkeld JA, French GL. Evidence that contaminated surfaces contribute to the transmission of hospital pathogens and an overview of strategies to address contaminated surfaces in hospital settings. Am J Infect Control. 2013;41(5 Suppl):S6-11.
Otter JA, Yezli S, French GL. The role played by contaminated surfaces in the transmission of nosocomial pathogens. Infect Control Hosp Epidemiol. 2011;32(7):687–99.
Wolfensberger A, Clack L, Kuster SP, Passerini S, Mody L, Chopra V, et al. Transfer of pathogens to and from patients, healthcare providers, and medical devices during care activity-a systematic review and meta-analysis. Infect Control Hosp Epidemiol. 2018;39(9):1093–107.
Ray AJ, Hoyen CK, Taub TF, Eckstein EC, Donskey CJ. Nosocomial transmission of vancomycin-resistant enterococci from surfaces. JAMA. 2002;287(11):1400–1.
Drees M, Snydman DR, Schmid CH, Barefoot L, Hansjosten K, Vue PM, et al. Prior environmental contamination increases the risk of acquisition of vancomycin-resistant enterococci. Clin Infect Dis. 2008;46(5):678–85.
Huang SS, Datta R, Platt R. Risk of acquiring antibiotic-resistant bacteria from prior room occupants. Arch Intern Med. 2006;166(18):1945–51.
Weber DJ, Anderson D, Rutala WA. The role of the surface environment in healthcare-associated infections. Curr Opin Infect Dis. 2013;26(4):338–44.
Stiller A, Salm F, Bischoff P, Gastmeier P. Relationship between hospital ward design and healthcare-associated infection rates: a systematic review and meta-analysis. Antimicrob Resist Infect Control. 2016;5:51.
McDonald EG, Dendukuri N, Frenette C, Lee TC. Time-series analysis of health care-associated infections in a new hospital with all private rooms. JAMA Intern Med. 2019;179(11):1501–6.
Duckro AN, Blom DW, Lyle EA, Weinstein RA, Hayden MK. Transfer of vancomycin-resistant enterococci via health care worker hands. Arch Intern Med. 2005;165(3):302–7.
Hayden MK, Blom DW, Lyle EA, Moore CG, Weinstein RA. Risk of hand or glove contamination after contact with patients colonized with vancomycin-resistant enterococcus or the colonized patients’ environment. Infect Control Hosp Epidemiol. 2008;29(2):149–54.
Randle J, Arthur A, Vaughan N. Twenty-four-hour observational study of hospital hand hygiene compliance. J Hosp Infect. 2010;76(3):252–5.
Cassone M, Mantey J, Perri MB, Gibson K, Lansing B, McNamara S, et al. Environmental panels as a proxy for nursing facility patients with methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus colonization. Clin Infect Dis. 2018;67(6):861–8.
Giannini MA, Nance D, McCullers JA. Are toilet seats a vector for transmission of methicillin-resistant Staphylococcus aureus? Am J Infect Control. 2009;37(6):505–6.
Scotoni M, Koch J, Julian TR, Clack L, Pitol AK, Wolfensberger A, et al. Silica nanoparticles with encapsulated DNA (SPED)—a novel surrogate tracer for microbial transmission in healthcare. Antimicrob Resist Infect Control. 2020;9(1):152.
Oelberg DG, Joyner SE, Jiang X, Laborde D, Islam MP, Pickering LK. Detection of pathogen transmission in neonatal nurseries using DNA markers as surrogate indicators. Pediatrics. 2000;105(2):311–5.
Thakur M, Alhmidi H, Cadnum JL, Jencson AL, Bingham J, Wilson BM, et al. Use of viral DNA surrogate markers to study routes of transmission of healthcare-associated pathogens. Infect Control Hosp Epidemiol. 2020;42:1–6.
Alhmidi H, Cadnum JL, Jencson AL, Gweder AA, Donskey CJ. Sharing is not always a good thing: Use of a DNA marker to investigate the potential for ward-to-ward dissemination of healthcare-associated pathogens. Infect Control Hosp Epidemiol. 2019;40(2):214–6.
Alhmidi H, John A, Mana TC, Koganti S, Cadnum JL, Shelton MB, et al. Evaluation of viral surrogate markers for study of pathogen dissemination during simulations of patient care. Open Forum Infect Dis. 2017;4(3):ofx128.
John A, Alhmidi H, Cadnum JL, Jencson AL, Donskey CJ. Contaminated portable equipment is a potential vector for dissemination of pathogens in the intensive care unit. Infect Control Hosp Epidemiol. 2017;38(10):1247–9.
Alhmidi H, Koganti S, Cadnum JL, Jencson AL, John A, Donskey CJ. Dissemination of a nonpathogenic viral DNA surrogate marker from high-touch surfaces in rooms of long-term care facility residents. Am J Infect Control. 2017;45(10):1165–7.
Koganti S, Alhmidi H, Tomas ME, Cadnum JL, Jencson A, Donskey CJ. Evaluation of hospital floors as a potential source of pathogen dissemination using a nonpathogenic virus as a surrogate marker. Infect Control Hosp Epidemiol. 2016;37(11):1374–7.
Tomas ME, Cadnum JL, Mana TS, Jencson AL, Koganti S, Alhmidi H, et al. Utility of a novel reflective marker visualized by flash photography for assessment of personnel contamination during removal of personal protective equipment. Infect Control Hosp Epidemiol. 2016;37(6):711–3.
Alhmidi H, Li DF, Cadnum JL, Haq MF, Pinto-Herrera NC, Wilson BM, et al. Use of simulations to evaluate the effectiveness of barrier precautions to prevent patient-to-patient transfer of healthcare-associated pathogens. Infect Control Hosp Epidemiol. 2020;42:1–6.
Alhmidi H, Koganti S, Tomas ME, Cadnum JL, Jencson A, Donskey CJ. A pilot study to assess use of fluorescent lotion in patient care simulations to illustrate pathogen dissemination and train personnel in correct use of personal protective equipment. Antimicrob Resist Infect Control. 2016;5:40.
Paunescu D, Puddu M, Soellner JO, Stoessel PR, Grass RN. Reversible DNA encapsulation in silica to produce ROS-resistant and heat-resistant synthetic DNA ‘fossils.’ Nat Protoc. 2013;8(12):2440–8.
Grass RN, Schälchli J, Paunescu D, Soellner JOB, Kaegi R, Stark WJ. Tracking trace amounts of submicrometer silica particles in wastewaters and activated sludge using silica-encapsulated DNA barcodes. Environ Sci Technol Lett. 2014;1(12):484–9.
Bloch MS, Paunescu D, Stoessel PR, Mora CA, Stark WJ, Grass RN. Labeling milk along its production chain with DNA encapsulated in silica. J Agric Food Chem. 2014;62(43):10615–20.
Mora CA, Paunescu D, Grass RN, Stark WJ. Silica particles with encapsulated DNA as trophic tracers. Mol Ecol Resour. 2015;15(2):231–41.
Mikutis G, Deuber CA, Schmid L, Kittila A, Lobsiger N, Puddu M, et al. Silica-encapsulated DNA-based tracers for aquifer characterization. Environ Sci Technol. 2018;52(21):12142–52.
Croissant JG, Fatieiev Y, Khashab NM. Degradability and clearance of silicon, organosilica, silsesquioxane, silica mixed oxide, and mesoporous silica nanoparticles. Adv Mater. 2017;29(9):1604634.
Huslage K, Rutala WA, Sickbert-Bennett E, Weber DJ. A quantitative approach to defining “high-touch” surfaces in hospitals. Infect Control Hosp Epidemiol. 2010;31(8):850–3.
Drankiewicz D, Dundes L. Handwashing among female college students. Am J Infect Control. 2003;31(2):67–71.
Shams AM, Rose LJ, Edwards JR, Cali S, Harris AD, Jacob JT, et al. Assessment of the overall and multidrug-resistant organism bioburden on environmental surfaces in healthcare facilities. Infect Control Hosp Epidemiol. 2016;37(12):1426–32.
Eckstein BC, Adams DA, Eckstein EC, Rao A, Sethi AK, Yadavalli GK, et al. Reduction of clostridium difficile and vancomycin-resistant enterococcus contamination of environmental surfaces after an intervention to improve cleaning methods. BMC Infect Dis. 2007;7:61.
Pearman JW. Lowbury Lecture: the Western Australian experience with vancomycin-resistant enterococci—from disaster to ongoing control. J Hosp Infect. 2004;63:14–26.
Vuichard-Gysin D, Schlegel MT, Senn N, Marschall L, Blanc J, Buetti DS, Egli N, A, Kuster SK, Balmelli A, Sommerstein C, Nartey R, Masserey Spicher L, Gardiol V, C, Widmer AF, Harbarth S. Eindämmung der Verbreitung von Vancomycin-resistenten Enterokokken (VRE) in der Schweiz: Aktualisierung der nationalen Empfehlungen. VRE task force, on behalf of Swissnoso; 2019.
Longtin Y, Schneider A, Tschopp C, Renzi G, Gayet-Ageron A, Schrenzel J, et al. Contamination of stethoscopes and physicians’ hands after a physical examination. Mayo Clin Proc. 2014;89(3):291–9.
O’Flaherty N, Fenelon L. The stethoscope and healthcare-associated infection: a snake in the grass or innocent bystander? J Hosp Infect. 2015;91(1):1–7.
Brady RRW, Wasson A, Stirling I, McAllister C, Damani NN. Is your phone bugged? The incidence of bacteria known to cause nosocomial infection on healthcare workers’ mobile phones. J Hosp Infect. 2006;62(1):123–5.
Simmonds R, Lee D, Hayhurst E. Mobile phones as fomites for potential pathogens in hospitals: microbiome analysis reveals hidden contaminants. J Hosp Infect. 2020;104(2):207–13.
Martina PF, Martinez M, Centeno CK, Von Specht M, Ferreras J. Dangerous passengers: multidrug-resistant bacteria on hands and mobile phones. J Prev Med Hyg. 2019;60(4):E293–9.
Widmer FC, Frei R, Romanyuk A, Tschudin Sutter S, Widmer AF. Overall bioburden by total colony count does not predict the presence of pathogens with high clinical relevance in hospital and community environments. J Hosp Infect. 2019;101(2):240–4.
Houghton C, Meskell P, Delaney H, Smalle M, Glenton C, Booth A, et al. Barriers and facilitators to healthcare workers’ adherence with infection prevention and control (IPC) guidelines for respiratory infectious diseases: a rapid qualitative evidence synthesis. Cochrane Database Syst Rev. 2020;4:CD013582.
Israel S, Harpaz K, Radvogin E, Schwartz C, Gross I, Mazeh H, et al. Dramatically improved hand hygiene performance rates at time of coronavirus pandemic. Clin Microbiol Infect. 2020;26(11):1566–8.